Lack of involvement of monoamine oxidase inhibition in the lethality of acute poisoning by chlordimeform.
Lack of involvement of monoamine oxidase inhibition in the lethality of acute poisoning by chlordimeform.
复制标题
单胺氧化酶抑制作用与杀虫脒急性中毒致死率无关。
DOI：
--
复制
发表时间：
1977
期刊：
影响因子：
--
通讯作者：
P. W. Smith
中科院分区：
文献类型：
--
作者：
C. Robinson;P. W. Smith
用对氯苯丙氨酸或DL-α-甲基-对酪氨酸分别对雄性大鼠耗尽5-羟色胺或去甲肾上腺素，均不能降低单胺氧化酶抑制杀螨剂敌百虫的致死率。苯肾上腺素是一种直接作用的α-肾上腺素能激动剂，与敌百虫一起使用并不会增加敌百虫的致死率。因此，敌百虫对单胺氧化酶的抑制似乎与其致命性无关。
Depletion of serotonin or norepinephrine in male rats by pretreatment with p-chlorophenylalanine or DL-alpha-methyl-p-tyrosine, respectively, failed to reduce the lethality of the monoamine oxidase-inhibiting acaricide, chlordimeform. Administration of phenylephrine, a directly acting alpha-adrenergic agonist, with chlordimeform did not increase the lethality of chlordimeform. Thus, monoamine oxidase inhibition by chlordimeform does not seem to contribute to its lethality.