Interaction between Flavivirus and Cytoskeleton during Virus Replication.
Interaction between Flavivirus and Cytoskeleton during Virus Replication.
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DOI：
10.1155/2015/427814
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发表时间：
2015
影响因子：
--
通讯作者：
Chee HY
中科院分区：
文献类型：
--
作者：
Foo KY;Chee HY
黄病毒是潜在的人类病原体，在世界范围内引起重大流行病。黄病毒与宿主细胞因子相互作用形成有利的病毒复制位点。细胞骨架被观察到与黄病毒有密切的联系，这扩大了对病毒复制过程中细胞骨架功能的理解，尽管许多详细的机制仍不清楚。病毒与宿主细胞骨架如肌动蛋白丝、微管和中间丝之间的相互作用为病毒感染过程中的分子改变提供了深入的了解，如病毒进入、细胞内运输、支架组装和外出。本文就黄病毒对细胞骨架的利用及其在病毒复制过程中的作用作一综述。
Flaviviruses are potentially human pathogens that cause major epidemics worldwide. Flavivirus interacts with host cell factors to form a favourable virus replication site. Cell cytoskeletons have been observed to have close contact with flaviviruses, which expands the understanding of cytoskeleton functions during virus replication, although many detailed mechanisms are still unclear. The interactions between the virus and host cytoskeletons such as actin filaments, microtubules, and intermediate filaments have provided insight into molecular alterations during the virus infection, such as viral entry, in-cell transport, scaffold assembly, and egress. This review article focuses on the utilization of cytoskeleton by Flavivirus and the respective functions during virus replication.