Bile formation and secretion.
Bile formation and secretion.
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DOI：
10.1002/cphy.c120027
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发表时间：
2013-07
影响因子：
5.8
通讯作者：
Boyer JL
中科院分区：
文献类型：
--
作者：
Boyer JL
胆汁是肝脏中一种独特而重要的含水分泌物，由肝细胞形成，并通过胆管上皮的吸收和分泌特性向下游调节。大约5%的胆汁由相当复杂的有机和无机溶质组成。胆汁分泌单位由邻近肝细胞顶膜形成的小管网络组成，并由紧密连接密封。胆小管直径约1μm，引导胆汁逆流至门静脉血流方向，与胆管相连，在胆汁进入胆总管、胆总管和肠道之前，胆小管的直径和复杂性逐渐增大。胆小管胆汁分泌是由胆盐依赖和独立的转运系统决定的，这些转运系统定位于肝细胞顶膜，主要由一系列三磷酸腺苷结合盒转运蛋白组成，作为胆盐和其他有机溶质的输出泵。这些转运蛋白在胆小管管腔内产生渗透梯度，为液体通过水通道蛋白进入管腔提供动力。不同种类的胆汁盐依赖和独立的胆小管血流和胆管细胞分泌的相对量不同，胆管细胞分泌受到激素、第二信使和信号转导途径的高度调节。在动物模型和人类中，胆汁分泌的大多数决定因素现在都是在分子水平上表征的。基因突变有助于阐明它们的许多功能。
Bile is a unique and vital aqueous secretion of the liver that is formed by the hepatocyte and modified down stream by absorptive and secretory properties of the bile duct epithelium. Approximately 5% of bile consists of organic and inorganic solutes of considerable complexity. The bile-secretory unit consists of a canalicular network which is formed by the apical membrane of adjacent hepatocytes and sealed by tight junctions. The bile canaliculi (~1 μm in diameter) conduct the flow of bile countercurrent to the direction of portal blood flow and connect with the canal of Hering and bile ducts which progressively increase in diameter and complexity prior to the entry of bile into the gallbladder, common bile duct, and intestine. Canalicular bile secretion is determined by both bile salt-dependent and independent transport systems which are localized at the apical membrane of the hepatocyte and largely consist of a series of adenosine triphosphate-binding cassette transport proteins that function as export pumps for bile salts and other organic solutes. These transporters create osmotic gradients within the bile canalicular lumen that provide the driving force for movement of fluid into the lumen via aquaporins. Species vary with respect to the relative amounts of bile salt-dependent and independent canalicular flow and cholangiocyte secretion which is highly regulated by hormones, second messengers, and signal transduction pathways. Most determinants of bile secretion are now characterized at the molecular level in animal models and in man. Genetic mutations serve to illuminate many of their functions.
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影响因子：
4.8
作者：
Abu-Hayyeh, Shadi;Martinez-Becerra, Pablo;Williamson, Catherine
通讯作者：
Williamson, Catherine
DOI：
10.1152/ajpgi.1997.273.2.g303
发表时间：
1997-08-01
影响因子：
4.5
作者：
Alvaro, D;Mennone, A;Boyer, JL
通讯作者：
Boyer, JL
影响因子：
15.9
作者：
Alvaro, D;Alpini, G;Benedetti, A
通讯作者：
Benedetti, A
影响因子：
15.9
作者：
ALVARO, D;CHO, WK;BOYER, JL
通讯作者：
BOYER, JL
影响因子：
29.4
作者：
Alpini, G;Glaser, SS;LeSage, GD
通讯作者：
LeSage, GD