Hair growth-promoting activities of chitosan and surface-deacetylated chitin nanofibers
Hair growth-promoting activities of chitosan and surface-deacetylated chitin nanofibers
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DOI：
10.1016/j.ijbiomac.2018.12.135
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发表时间：
2019-04-01
影响因子：
8.2
通讯作者：
Ifuku, Shinsuke
中科院分区：
文献类型：
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作者：
Azuma, Kazuo;Koizumi, Ryo;Ifuku, Shinsuke
在这项研究中，评估了壳聚糖和表面脱乙酰甲壳素纳米纤维(SDACNF)对头发生长的影响。在体外培养的人毛囊毛乳头细胞中，壳聚糖和SDACNF在作用3d后促进细胞生长，并在3d时增加成纤维细胞生长因子-7(FGF-7)的产生。此外，在小鼠体内研究中，壳聚糖和SDACNF应用促进毛发生长。与对照组相比，壳聚糖组和SDACNF组生长期卵泡数显著增加，而休止期卵泡数显著减少。此外，壳聚糖组和SDACNFs组毛囊中成纤维细胞生长因子-7和Sonic Hedgehog的表达水平显著上调。总体而言，我们的结果表明，壳聚糖和SDACNFs促进了头发的生长，因此可能会作为治疗脱发的新型治疗剂而得到应用。(C)2018爱思唯尔B.V.保留所有权利。
In this study, the effects of chitosan and surface-deacetylated chitin nanofibrils (SDACNFs) on hair growth were evaluated. In human follicle dermal papilla cells in vitro, chitosan and SDACNFs were shown to increase cell growth on day 3 after the initiation of treatment, together with an increase in the production of fibroblast growth factor-7 (FGF-7) by these cells on day 3. Furthermore, in an in vivo study in mice, chitosan and SDACNF application promoted hair growth. The number of anagen follicles significantly increased compared with that in the control group, whereas the number of telogen follicles significantly decreased in the chitosan and SDACNF groups. In the chitosan and SDACNFs groups, moreover, the expression levels of FGF-7 and Sonic hedgehog were significantly upregulated in hair follicles. Overall, our results demonstrated that chitosan and SDACNFs promoted hair growth and therefore may have applications as novel therapeutic agents for the treatment of hair loss in patients. (C) 2018 Elsevier B.V. All rights reserved.