One-Pot Synthesis of Triazolobenzodiazepines Through Decarboxylative [3+2] Cycloaddition of Nonstabilized Azomethine Ylides and Cu-Free Click Reactions
One-Pot Synthesis of Triazolobenzodiazepines Through Decarboxylative [3+2] Cycloaddition of Nonstabilized Azomethine Ylides and Cu-Free Click Reactions
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DOI：
10.3390/molecules24030601
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发表时间：
2019-02-01
期刊：
影响因子：
4.6
通讯作者：
Zhang, Wei
中科院分区：
文献类型：
--
作者：
Ma, Xiaoming;Zhang, Xiaofeng;Zhang, Wei
介绍了一种一锅法合成含三唑并苯并二氮杂卓多环化合物的方法。反应过程包括不稳定的甲亚胺叶立德的脱羧三组分[3 + 2]环加成、N-炔丙基化和分子内点击反应。
A one-pot synthesis of triazolobenzodiazepine-containing polycyclic compounds is introduced. The reaction process involves a decarboxylative three-component [3 + 2] cycloaddition of nonstabilized azomethine ylides, N-propargylation, and intramolecular click reactions.