Motor activation by amphetamine infusion into nucleus accumbens core and shell subregions of rats differentially sensitive to dopaminergic drugs
Motor activation by amphetamine infusion into nucleus accumbens core and shell subregions of rats differentially sensitive to dopaminergic drugs
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DOI：
10.1016/s0166-4328(98)00064-3
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发表时间：
1998-12
影响因子：
2.7
通讯作者：
C. H. West;Katherine A. Boss-Williams;J. Weiss
中科院分区：
文献类型：
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作者：
C. H. West;Katherine A. Boss-Williams;J. Weiss
基于游泳测试活动的选择性育种已被用于培育在游泳测试中表现出高活动水平(Swim High-Active(SwHi)大鼠)和在游泳测试中表现出低活动水平(Swim Low-Active(SwLo)大鼠)的大鼠品系。以前的研究表明，SwHi大鼠的多巴胺(DA)功能增强，SwLo大鼠的多巴胺(DA)功能降低；一个主要发现是，全身应用苯丙胺后，SwLo大鼠的活动活动增加幅度比SwHi或非选择的大鼠小得多。鉴于伏隔核(NAC)在苯丙胺活动中的重要性，本研究探讨了SwHi和SwLo大鼠在NAC的DA功能是否不同。将苯丙胺注入NAC的核心区或壳区，然后测量步行或游泳测试活动。在SwLO大鼠中，向NAc核或壳内注入苯丙胺(0.22.0μg)均可使大鼠的行走能力适度增加。在SwHi大鼠中，将安非他明注入NAC壳内也产生了类似的中等程度的行走增加，但向核心区注入苯丙胺产生了明显更大的与剂量相关的行走增加。在游泳实验中，注入安非他明(1.0μg)通过影响每条线的优势行为来增加活性；即在SwHi大鼠中挣扎增加，在SwLo大鼠中漂浮减少，在注入NAC核心或外壳时对这两条线都有很大的影响。这些结果支持以下观点：SwHi和SwLo大鼠不同的行为特征部分是由NAC-DA功能的差异所致。
Selective breeding based on activity in a swim test has been used to produce lines of rats that show a high level of activity in the swim test (Swim High-active (SwHi) rats) and a low level of activity in the swim test (Swim Low-active (SwLo) rats). Previous studies have indicated that dopamine (DA) function is enhanced in SwHi rats and reduced in SwLo rats; a principal finding was that SwLo rats showed much smaller increases in ambulatory activity after systemic administration of amphetamine than did SwHi or non-selected rats. In light of the importance of the nucleus accumbens (NAC) in amphetamine-induced activity, the present study investigated whether DA function in NAC differs in SwHi and SwLo rats. Amphetamine was infused bilaterally into either the core or shell subregion of NAC, and ambulation or swim test activity was then measured. In SwLo rats, infusion of amphetamine (0.2–2.0 μg) into either NAC core or shell produced moderate increases in ambulation. In SwHi rats, infusion of amphetamine into NAC shell produced similar moderate increases in ambulation, but infusion into the core produced markedly larger dose-related increases in ambulation. In the swim test, infusion of amphetamine (1.0 μg) increased activity by affecting the dominant behavior of each line; i.e. struggling increased in SwHi rats and floating decreased in SwLo rats, with large effects seen in both lines with infusion into either NAC core or shell. These results support the idea that the distinct behavioral characteristics of SwHi and SwLo rats are mediated in part by differences in NAC-DA function.