Regulation of translation by stress granules and processing bodies.
Regulation of translation by stress granules and processing bodies.
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DOI：
10.1016/s1877-1173(09)90004-7
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发表时间：
2009
影响因子：
--
通讯作者：
Anderson P
中科院分区：
文献类型：
--
作者：
Kedersha N;Anderson P
压力需要翻译的快速重编程，以促进适应性反应和促进生存。细胞质应激颗粒（SG）和加工体（PB）是响应应激诱导的翻译停滞而形成的动态结构。PB与mRNA沉默和衰变有关，而SG与翻译和针对不同命运的特定mRNA的分选更密切相关。虽然它们共享一些组件并且可以物理地相互作用，但SG和PB独立地调节，具有单独的功能，并且含有独特的标记物。SG形成与许多疾病状态相关，并且SG相关蛋白的扩展列表将SG形成与其他过程如转录、剪接和存活整合。越来越多的证据表明，SG组装是由翻译停滞启动的，并介导与许多其他信号通路的串扰。
Stress necessitates rapid reprogramming of translation in order to facilitate an adaptive response and promote survival. Cytoplasmic stress granules (SGs) and processing bodies (PBs) are dynamic structures that form in response to stress-induced translational arrest. PBs are linked to mRNA silencing and decay, while SGs are more closely linked to translation and the sorting of specific mRNAs for different fates. While they share some components and can interact physically, SGs and PBs are regulated independently, house separate functions, and contain unique markers. SG formation is associated with numerous disease states, and the expanding list of SG-associated proteins integrates SG formation with other processes such as transcription, splicing, and survival. Growing evidence suggests that SG assembly is initiated by translational arrest, and mediates cross talk with many other signaling pathways.