CORRELATION OF GENERAL ANESTHETIC POTENCY WITH SOLUBILITY IN MEMBRANES
CORRELATION OF GENERAL ANESTHETIC POTENCY WITH SOLUBILITY IN MEMBRANES
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DOI：
10.1016/0005-2736(81)90017-1
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发表时间：
1981-01-01
期刊：
影响因子：
--
通讯作者：
MILLER, KW
中科院分区：
文献类型：
--
作者：
JANOFF, AS;PRINGLE, MJ;MILLER, KW
最近有人声称，当将烷醇与其他挥发性麻醉剂进行比较时，麻醉剂效力和植物油溶解度之间的传统相关性被打破。最近，关于麻醉剂分配成脂质双层的新信息已经变得可用。在这份报告中，21种结构不同的麻醉剂的效力与它们分配成磷脂酰胆碱双层的能力密切相关。因此，当脂双层溶解度取代油溶解度时，原始的Meyer-Overton油溶解度假说适应了更广泛的麻醉剂，包括烷醇、挥发性和气体试剂以及巴比妥酸盐。
Recently it was claimed that the traditional correlation between anesthetic potency and vegetable oil solubility breaks down when the alkanols are compared to other volatile anesthetics. Lately, new information on the partitioning of anesthetics into lipid bilayers has become available. In this report the potency of 21 structurally diverse anesthetic agents is shown to correlate well with their ability to partition into phosphatidylcholine bilayers. Thus the original Meyer-Overton oil solubility hypothesis accomodates a wider range of anesthetics, including alkanols, volatile and gaseous agents, and barbiturates, when lipid bilayer solubility is substituted for oil solubility.