THE KINETICS OF REPAIR IN MOUSE LUNG AFTER FRACTIONATED-IRRADIATION
THE KINETICS OF REPAIR IN MOUSE LUNG AFTER FRACTIONATED-IRRADIATION
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DOI：
10.1080/09553008714552491
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发表时间：
1987-12-01
影响因子：
2.6
通讯作者：
KISS, I
中科院分区：
文献类型：
--
作者：
TRAVIS, EL;THAMES, HD;KISS, I
研究了在分次剂量的 137Cs γ-射线后小鼠肺部亚致死损伤修复的动力学。每次分次给予多种剂量（1.7-12 Gy），分次间隔范围为 0.5 至 24 小时。使用不完全修复模型通过直接分析方法对数据进行分析。肺炎损伤阶段（长达 8 个月）的修复半衰期（T1/2）为 0.76 小时，损伤后期阶段（长达 12 个月）的修复半衰期为 0.65 小时。修复速度取决于肺损伤两个阶段的分次大小，并且大剂量分次后比小剂量分次后修复速度更快。对于每次剂量大于 5 Gy 的 T1/2 为 0.6 小时（95% c.1. 0.53, 0.69），对于每次剂量 2 Gy 的 T1/2 为 0.83 小时（95% c.1. 0.76, 0.92）。修复工作在 6 小时内几乎完成，至少在肺炎损伤阶段是这样。就这些数据外推到人类可能有效的程度而言，这些结果意味着每天进行多次涉及肺部的分次治疗不会受到分次间隔远长于 6 小时的必要性的限制。
The kinetics of repair of sublethal damage in mouse lung was studied after fractionated doses of 137Cs .gamma.-rays. A wide range of doses per fraction (1.7-12 Gy) was given with interfraction intervals ranging from 0.5 to 24h. The data were analysed by a direct method of analysis using the incomplete repair model. The half-time of repair (T1/2) was 0.76 h for the pneumonitis phase of damage (up to 8 months) and 0.65 h for the later phase of damage up to 12 months. The rate of repair was dependent on fraction size for both phases of lung damage and was faster after large dose fractions than after small fractions. The T1/2 was 0.6 h (95 per cent c.1. 0.53, 0.69) for doses per fraction greater than 5 Gy and 0.83 h (95 per cent c.1. 0.76, 0.92) for doses per fraction of 2 Gy. Repair was nearly complete by 6 h, at least for the pneumonitis phase of damage. To the extent the extrapolation of these data to humans may be valid, these results imply that treatments with multiple fractions per day that involve the lung will not be limited by the necessity for interfraction intervals much longer than 6 h.