The relationship between socioeconomic indices and potentially zoonotic pathogens carried by wild Norway rats: a survey in Rhône, France (2010-2012).
The relationship between socioeconomic indices and potentially zoonotic pathogens carried by wild Norway rats: a survey in Rhône, France (2010-2012).
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DOI：
10.1017/s0950268814001137
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发表时间：
2015-02
影响因子：
4.2
通讯作者：
Artois M
中科院分区：
文献类型：
--
作者：
Ayral F;Artois J;Zilber AL;Widén F;Pounder KC;Aubert D;Bicout DJ;Artois M
问号钩端螺旋体、汉坦病毒（特别是首尔病毒）、戊型肝炎病毒（HEV）和刚地弓形虫是与大鼠相关的人畜共患病，在世界范围内引起人类发病和死亡。本研究旨在描述法国里昂社区不同社会经济水平的野鼠（褐家鼠）中这四种病原体的感染模式。使用聚合酶链反应或血清学方法确定了在23个地点捕获的178只野鼠的感染或接触状况;此外，还进行了确证性培养或小鼠接种。采用多因素logistic回归分析，探讨形态学和社会经济学数据是否可以预测大鼠的感染状况。提示鼠群的年龄结构可能影响L.汉坦病毒和戊型肝炎病毒。此外，人口密度高和收入低的地区可能与受感染的老鼠数量更多和疾病传播风险增加有关。
Leptospira interrogans, hantaviruses (particularly Seoul virus), hepatitis E virus (HEV), and Toxoplasma gondii are rat-associated zoonoses that are responsible for human morbidity and mortality worldwide. This study aimed to describe the infection patterns of these four pathogens in wild rats (Rattus norvegicus) across socioeconomic levels in neighbourhoods in Lyon, France. The infection or exposure status was determined using polymerase chain reaction or serology for 178 wild rats captured in 23 locations; additionally, confirmatory culture or mouse inoculation was performed. Multivariate logistic regression analyses were used to investigate whether morphological and socioeconomic data could predict the infection status of the rats. This study revealed that the rat colony's age structure may influence the prevalence of L. interrogans, hantavirus, and HEV. In addition, areas with high human population densities and low incomes may be associated with a greater number of infected rats and an increased risk of disease transmission.