Patient-Specific Flow Descriptors and Normalized wall index in Peripheral Artery Disease: a Preliminary Study.
Patient-Specific Flow Descriptors and Normalized wall index in Peripheral Artery Disease: a Preliminary Study.
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DOI：
10.1080/21681163.2016.1184589
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Decuzzi P
中科院分区：
文献类型：
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作者：
Singh J;Brunner G;Morrisett JD;Ballantyne CM;Lumsden AB;Shah DJ;Decuzzi P
基于MRI的血流动力学已被应用于研究时间平均壁面剪切应力（TAWSS），振荡剪切指数（OSI）和冠状动脉，颈动脉和人体主动脉粥样硬化病变之间的关系。然而，TAWSS和OSI在下肢动脉中的作用知之甚少。本研究的目的是探讨外周动脉疾病（PAD）患者股浅动脉（SFA）血流动力学评估的可行性，我们假设TAWSS和OSI分别与动脉粥样硬化负荷（以标准化壁指数（NWI）表示）相关。从患者特定MRI数据（包括基线、12个月和24个月）中提取了6例SFA的3D血管几何形状和相关入口/出口血流条件。进行血流模拟以计算流动描述符，包括TAWSS和OSI以及NWI。NWI与TAWSS呈正相关（r = 0.592; p < 0.05）。NWI与OSI呈负相关（相关系数：r =-0.310，p < 0.01）。空间平均TAWSS和平均NWI在基线和24个月之间显著增加，而OSI在2年内下降。在这项样本量有限的初步研究中，TAWSS与NWI呈正相关，而OSI显示出负相关关系。然而，我们的发现需要在更大的前瞻性研究中进行验证。基于MRI的股浅动脉血流动力学研究是可行的。
MRI-based hemodynamics have been applied to study the relationship between time-averaged wall shear stresses (TAWSS), oscillatory shear index (OSI) and atherosclerotic lesions in the coronary arteries, carotid artery, and human aorta. However, the role of TAWSS and OSI are poorly understood in lower extremity arteries. The aim of this work was to investigate the feasibility of hemodynamic assessment of the superficial femoral artery (SFA) in patients with peripheral artery disease (PAD) and we hypothesized that there is an association between TAWSS and OSI, respectively, and atherosclerotic burden expressed as the normalized wall index (NWI). Six cases of 3D vascular geometries of the SFA and related inlet/outlet flow conditions were extracted from patient-specific MRI data including baseline, 12 and 24 months. Blood flow simulations were performed to compute flow descriptors, including TAWSS and OSI, and NWI. NWI was correlated positively with TAWSS (correlation coefficient: r = 0.592; p < 0.05). NWI was correlated negatively with OSI (correlation coefficient: r = −0.310, p < 0.01). Spatially averaged TAWSS and average NWI increased significantly between baseline and 24-months, whereas OSI decreased over 2-years. In this pilot study with a limited sample size, TAWSS was positively associated with NWI, a measure of plaque burden, whereas OSI showed an inverse relationship. However, our findings need to be verified in a larger prospective study. MRI-based study of hemodynamics is feasible in the superficial femoral artery.