Time-dependent increases in cue-induced reinstatement of sucrose seeking after sucrose self-administration in adolescence
Time-dependent increases in cue-induced reinstatement of sucrose seeking after sucrose self-administration in adolescence
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DOI：
10.1016/j.bbr.2010.04.011
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发表时间：
2010-11-12
影响因子：
2.7
通讯作者：
Frantz, Kyle J.
中科院分区：
文献类型：
--
作者：
Li, Chen;Frantz, Kyle J.
之前我们报道过，与成年大鼠相比，在青少年时期自我给予可卡因的大鼠中，提示诱导的可卡因寻求恢复的时间依赖性增加减弱（Li和Frantz（2009）[12]）。现在使用蔗糖自我管理，我们报告的时间依赖性增加线索诱导恢复蔗糖寻求是相似的年龄组，这表明恢复可卡因寻求的年龄差异取决于可卡因的具体影响，而不是年轻大鼠之间的妥协能力，将线索与奖励。(C)2010 Elsevier B.V.保留所有权利。
Previously we reported that time-dependent increases in cue-induced reinstatement of cocaine seeking were attenuated in rats self-administering cocaine as adolescents, compared with adults (Li and Frantz (2009) [12]). Now using sucrose self-administration, we report time-dependent increases in cue-induced reinstatement of sucrose seeking are similar across age groups, suggesting that age differences in reinstatement of cocaine seeking depend on specific effects of cocaine, not a compromised ability among younger rats to associate cues with rewards. (C) 2010 Elsevier B.V. All rights reserved.