One-Pot Synthesis of Optically Active Allyl Esters via Lipase-Vanadium Combo Catalysis
One-Pot Synthesis of Optically Active Allyl Esters via Lipase-Vanadium Combo Catalysis
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DOI：
10.1021/ol102053a
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发表时间：
2010-11-05
期刊：
影响因子：
5.2
通讯作者：
Egi, Masahiro
中科院分区：
文献类型：
--
作者：
Akai, Shuji;Hanada, Ryosuke;Egi, Masahiro
钒氧化合物（3或4）与脂肪酶的结合产生了外消旋盟友的区域和对映收敛转化。醇（1或2）变成具有光学活性的烯丙基酯。在该体系中，钒类化合物催化醇类随着羟基的转位连续外消旋化，而脂肪酶则通过化学选择性和对映选择性酯化来实现动态动力学分解。
The combination of vanadium-oxo compounds (3 or 4) with a lipase produced the regio- and enantioconvergent transformation of racemic ally! alcohols (1 or 2) into optically active allyl esters. In this system, the vanadium compounds catalyzed the continuous racemization of the alcohols along with the transposition of the hydroxyl group, while the lipase effected the chemo- and enantioselective esterification to achieve the dynamic kinetic resolution.