Looking at my body. Similarities and differences between anorexia nervosa patients and controls in body image visual processing
Looking at my body. Similarities and differences between anorexia nervosa patients and controls in body image visual processing
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DOI：
10.1016/j.eurpsy.2012.06.006
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发表时间：
2013-09-01
影响因子：
7.8
通讯作者：
Ricca, V.
中科院分区：
文献类型：
--
作者：
Castellini, G.;Polito, C.;Ricca, V.
背景：身体形象扭曲是饮食失调的核心症状。功能性磁共振成像（fMRI）对身体图像处理的研究描述了不同的神经反应模式，主要涉及顶叶下小叶和顶叶上小叶以及背外侧前额叶皮层（DLPFC），但结果相互矛盾。方法：应用功能磁共振成像技术，对18例神经性厌食症（AN）限制型女性患者和19例健康女性（HC）受试者对自身体型图片（正常和扭曲）的神经反应进行评价。临床评估采用DSM-IV的结构化临床访谈和自我报告问卷进行。结果：在身体图像失真的反应中，患者和对照组表现出相反的激活模式，an在过大的情况下激活程度最大，而HC在过小的情况下激活程度最大。AN和HC对自己的身体表现出相似的神经反应模式，在胃外体区、上、下顶叶和前额叶区域的激活增加，尽管HC的激活程度比AN患者更有限。与HC相比，AN患者的DLPFC活动增加，以应对超大的身体图像，并且在AN患者中发现DLPFC激活与饮食失调精神病理之间存在显著相关性。结论：我们的研究结果表明，神经对身体形象的反应存在从正常到病理的连续统一体，并证实了身体形象失真在AN中的临床相关性，强化了注意网络、执行网络和自我评价网络在AN对自身扭曲身体形象的视觉处理中的关键作用。(C) 2012 Elsevier Masson SAS。版权所有。
Background: Body image distortion is a core symptom of eating disorders. Functional magnetic resonance imaging (fMRI) studies on body image processing, described different patterns of neural response, mainly involving the inferior and superior parietal lobules, and the dorsolateral prefrontal cortex (DLPFC), with conflicting results.Methods: The neural response to the view of their own body pictures (normal size and distorted) was evaluated in 18 female anorexia nervosa (AN) restricting type patients, and in 19 healthy female subjects (HC) using fMRI. Clinical assessment was performed by means of the structured clinical interview for DSM-IV and self-reported questionnaires.Results: In response to the body image distortion, patients and controls showed an inverse pattern of activation, with the widest extent of activation in the oversize condition in AN, while in the undersize condition in HC. AN and HC showed a similar pattern of neural response to the view of their own body, with an increased activation in the extrastriate body area, superior and inferior parietal lobule and prefrontal areas, although the extent of activation in HC was more limited as compared with AN patients. Increased activity in AN patients, compared with HC, was observed in the DLPFC in response to the oversized body picture and a significant correlation was found in AN patients between DLPFC activation and eating disorder psychopathology.Conclusions: Our findings suggest the existence of a continuum from normalcy to pathology in neural response to body image, and confirm the clinical relevance of body image distortion in AN, reinforcing the key role of attentive, executive and self-evaluation networks in AN visual processing of own distorted body image. (C) 2012 Elsevier Masson SAS. All rights reserved.