The fate of XO germ cells in the testes of XO/XY and XO/XY/XYY mouse mosaics: evidence for a spermatogenesis gene on the mouse Y chromosome.
The fate of XO germ cells in the testes of XO/XY and XO/XY/XYY mouse mosaics: evidence for a spermatogenesis gene on the mouse Y chromosome.
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XO/XY 和 XO/XY/XYY 小鼠嵌合体睾丸中 XO 生殖细胞的命运：小鼠 Y 染色体上精子发生基因的证据。
DOI：
10.1159/000132280
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
P. Burgoyne
中科院分区：
文献类型：
--
作者：
E. Levy;P. Burgoyne
对九只 XO/XY 或 XO/XY/XYY 嵌合小鼠的细胞遗传学和组织学研究表明，XO 生殖细胞被选择性地从生精上皮中消除。尽管 7 只小鼠的 XO 对骨髓的贡献超过 50%，但只有 2 例小鼠存在大量分裂的 XO 精原细胞。这些 XO 生殖细胞仅偶尔进展到减数分裂，然后在第一次减数分裂中期之前退化。结论是，小鼠 Y 染色体携带一个在生殖细胞中自主作用的“精子发生基因”（或多个基因）。
A cytogenetic and histological study of nine XO/XY or XO/XY/XYY mosaic mice revealed that XO germ cells were selectively eliminated from the spermatogenic epithelium. Although the XO contribution to the bone marrow in seven mice exceeded 50%, in only two cases were significant numbers of dividing XO spermatogonia present. These XO germ cells only occasionally progressed to meiosis and then degenerated prior to first meiotic metaphase. It was concluded that the mouse Y chromosome carries a "spermatogenesis gene" (or genes) which acts autonomously in the germ cells.