In vitro effects of antimicrobial agents on planktonic and biofilm forms of Staphylococcus lugdunensis clinical isolates
In vitro effects of antimicrobial agents on planktonic and biofilm forms of Staphylococcus lugdunensis clinical isolates
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DOI：
10.1128/aac.01052-06
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发表时间：
2007-03-01
影响因子：
4.9
通讯作者：
Patel, Robin
中科院分区：
文献类型：
--
作者：
Frank, Kristi L.;Reichert, Emily J.;Patel, Robin
路邓葡萄球菌是一种致病性强的凝固酶阴性葡萄球菌，与急性和破坏性感染相关，通常类似于金黄色葡萄球菌感染。S. lugdunensis（例如，天然瓣膜心内膜炎、人工关节感染和血管内导管感染）与生物膜形成有关，由于生物膜抵抗高水平抗生素的固有性质，这可能导致不能根除感染。本研究测定了10种抗葡萄球菌抗菌药物对15株S.从患有心内膜炎、医疗器械感染或皮肤和软组织感染的患者中收集的路邓氏菌分离物。浮游分离物对所研究的所有药剂都敏感，但生物膜对高浓度的大多数药物具有抗性。然而，利福沙星能够杀死73%的生长在生物膜中的分离株，
Staphylococcus lugdunensis is an atypically virulent coagulase-negative staphylococcal species associated with acute and destructive infections that often resemble Staphylococcus aureus infections. Several types of infection caused by S. lugdunensis (e.g., native valve endocarditis, prosthetic joint infection, and intravascular catheter infection) are associated with biofilm formation, which may lead to an inability to eradicate the infection due to the intrinsic nature of biofilms to resist high levels of antibiotics. In this study, planktonic MICs and MBCs and biofilm bactericidal concentrations of 10 antistaphylococcal antimicrobial agents were measured for 15 S. lugdunensis isolates collected from patients with endocarditis, medical device infections, or skin and soft tissue infections. Planktonic isolates were susceptible to all agents studied, but biofilms were resistant to high concentrations of most of the drugs. However, moxifloxacin was able to kill 73% of isolates growing in biofilms at