Corpus callosum shape and neuropsychological deficits in adult males with heavy fetal alcohol exposure
Corpus callosum shape and neuropsychological deficits in adult males with heavy fetal alcohol exposure
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DOI：
10.1006/nimg.2001.0977
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发表时间：
2002-01-01
期刊：
影响因子：
5.7
通讯作者：
Barr, HM
中科院分区：
文献类型：
--
作者：
Bookstein, FL;Streissguth, AP;Barr, HM
由于产前酒精暴露而导致脑损伤的人通常被诊断为胎儿酒精综合征（FAS）或胎儿酒精效应（FAE），这取决于面部特征。在这些群体中，行为缺陷的差异很大。我们试图将联合收割机神经解剖学测量与神经认知和神经运动测量相结合，以提高对酒精暴露各种后果的敏感性。为此，胼胝体中线曲线的三维数字化仔细从T1加权磁共振扫描的15名成年男性诊断为FAS，15与FAE，和15谁是未暴露和临床正常。从5小时的神经心理学测试，我们提取了2600分数和评级有关的注意力，记忆力，执行功能，精细和粗大的运动表现，和智力。通过新的形态测量方法分析了胼胝体中线形状，并通过偏最小二乘分析了形状与行为的关系。FAS和FAE亚组的胼胝体形状的变异性明显高于我们的正常人。与过量的形状变化相关的是两种不同的行为缺陷的配置文件无关的全量表智商或FAS/FAE的区别在暴露亚组。相对厚的胼胝体与执行功能缺陷的模式有关;相对薄的胼胝体与运动功能缺陷有关。这两个联合收割机结合在一个非常有前途的双极歧视暴露从未暴露在这个样本。因此，胼胝体的形式有相当多的信息，神经心理缺陷的预后在这种常见的出生缺陷。(C)2002年，Elsevier Science。
Persons with brain damage consequent to prenatal alcohol exposure have typically been diagnosed with either fetal alcohol syndrome (FAS) or fetal alcohol effects (FAE), depending on facial features. There is great variability of behavioral deficits within these groups. We sought to combine neuroanatomical measures with neurocognitive and neuromotor measures in criteria of greater sensitivity over the variety of consequences of alcohol exposure. To this end, midline curves of the corpus callosum were carefully digitized in three dimensions from T1-weighted MR scans of 15 adult males diagnosed with FAS, 15 with FAE, and 15 who were unexposed and clinically normal. From 5 h of neuropsychological testing we extracted 2600 scores and ratings pertaining to attention, memory, executive function, fine and gross motor performance, and intelligence. Callosal midline shape was analyzed by new morphometric methods, and the relation of shape to behavior by partial least squares. The FAS and FAE subgroups have strikingly more variability of callosal shape than our normal subjects. With the excess shape variation are associated two different profiles of behavioral deficit unrelated to full-scale IQ or to the FAS/FAE distinction within the exposed subgroup. A relatively thick callosum is associated with a pattern of deficit in executive function; one that is relatively thin, with a deficit in motor function. The two combine in a very promising bipolar discrimination of the exposed from the unexposed in this sample. Thus there is considerable information in callosal form for prognosis of neuropsychological deficits in this frequently encountered birth defect. (C) 2002 Elsevier Science.