Unusual Pyrrolyl 4-Quinolinone Alkaloids from the Marine-Derived Fungus Penicillium sp ghq208
Unusual Pyrrolyl 4-Quinolinone Alkaloids from the Marine-Derived Fungus Penicillium sp ghq208
复制标题
来自海洋源性真菌青霉 sp ghq208 的不寻常吡咯基 4-喹啉酮生物碱
DOI：
10.1248/cpb.c12-00487
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发表时间：
2012-11-01
影响因子：
1.7
通讯作者：
Li, Dehai
中科院分区：
文献类型：
--
作者：
Gao, Huquan;Zhang, Lianqing;Li, Dehai
从海洋真菌Penicillium sp.ghq208中分离得到一个新的吡咯基4-喹啉酮生物碱penicinoline E（1），以及三个已知衍生物甲基penicinoline（2）、penicinoline（3）和quinolactacide（4）。通过波谱方法鉴定了这些化合物的结构。化合物（2，3）对HepG 2细胞系显示中等的细胞毒性，IC 50值分别为11.3和13.2 μ m。
One new pyrrolyl 4-quinolinone alkaloid, penicinoline E (1), together with three known deriverites, methyl-penicinoline (2), penicinoline (3), and quinolactacide (4), were isolated from the marine-derived fungus Penicillium sp. ghq208. The structures of these isolated compounds were elucidated by spectroscopic methods. Compounds (2, 3) exhibited moderate cytotoxicities against the HepG2 cell line with IC50 values of 11.3 and 13.2 mu m, respectively.