Biological feedback control-Respect the loops
Biological feedback control-Respect the loops
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DOI：
10.1016/j.cels.2021.05.004
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发表时间：
2021-06-16
期刊：
影响因子：
9.3
通讯作者：
El-Samad, Hana
中科院分区：
文献类型：
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作者：
El-Samad, Hana
我们，以及所有的有机体，都是多尺度反馈控制的进化杰作。反馈回路使我们的细胞能够生长，然后停在合适的大小，分裂和自我修复，并对不断变化的环境做出敏捷的反应。单个细胞与其他细胞进行长距离的细胞外反馈，确保我们的组织和器官的持续体内平衡。许多长距离反馈回路调节重要的生理变量。在这里，我认为，集中精力了解生物反馈控制网络的属性和约束应该是理解生命的核心。我还将提出这一领域的许多紧迫挑战，并审查可能对解决这些挑战产生重要影响的概念框架。
We, and all organisms, are an evolutionary masterpiece of multiscale feedback control. Feedback loops enable our cells to grow and then stop at the right size, to divide and self-repair, and to respond with agility to their changing environment. Individual cells engage in long range extracellular feedback with other cells, ensuring continued homeostasis of our tissues and organs. Many long ranging feedback loops regulate vital physiological variables. Here, I will argue that focused efforts to understand the properties and constraints of biological feedback control networks should be central to the quest of understanding life. I will also propose many pressing challenges in this field and review conceptual frameworks that might be consequential for addressing them.