Oxidative stress early in pregnancy and pregnancy outcome
Oxidative stress early in pregnancy and pregnancy outcome
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DOI：
10.1080/10715760802510069
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发表时间：
2008-01-01
影响因子：
3.3
通讯作者：
Rodriguez, Ana
中科院分区：
文献类型：
--
作者：
Stein, T. Peter;Scholl, Theresa O.;Rodriguez, Ana
本研究的目的是确定是否氧化应激在怀孕早期影响妊娠结局。将外源性和内源性抗氧化剂以及两种公认的氧化应激生物标志物（8-iso-PGF 2（脂质氧化的生物标志物，n=508）和8-氧代-7，8-二氢-2-脱氧鸟苷（8-OHdG，DNA氧化的生物标志物，n=487）的尿排泄）的试验组合使用。这两种生物标志物追踪不同的妊娠结果。异前列腺素与先兆子痫的风险增加和女婴比例下降有关。相比之下，8-OHdG追踪婴儿出生体重较低，妊娠期缩短。出生缺陷与低水平的8-OHdG有关。
The objectives of this study were to determine whether oxidative stress early in pregnancy influenced pregnancy outcome. A combination of assays were used for exogenous and endogenous anti-oxidants together with two well accepted biomarkers for oxidative stress, the urinary excretion of 8-iso-PGF2 (a biomarker marker for lipid oxidation, n=508) and 8-oxo-7,8 dihydro-2 deoxyguanosine (8-OHdG, a biomarker for DNA oxidation, n=487). The two biomarkers tracked different pregnancy outcomes. Isoprostanes were associated with an increased risk of pre-eclampsia and a decreased proportion of female births. In contrast, 8-OHdG tracked lower infant birthweight and shortened gestation duration. Birth defects were associated with low levels of 8-OHdG.