Intimal thickness is not associated with wall shear stress patterns in the human right coronary artery
Intimal thickness is not associated with wall shear stress patterns in the human right coronary artery
复制标题
DOI：
10.1161/01.atv.0000147118.97474.4b
复制
发表时间：
2004-12-01
影响因子：
8.7
通讯作者：
Ethier, CR
中科院分区：
文献类型：
--
作者：
Joshi, AK;Leask, RL;Ethier, CR
目的：低壁面切应力与动脉树（包括右冠状动脉）的动脉粥样硬化形成有关。本研究的目的是确定内膜厚度和壁面切应力在人类RCA.Methods和结果的协变水平-尸检内膜厚度的组织学测量进行了比较，从计算流模型在4人右冠状动脉壁面切应力。仅在研究的4条动脉中的1条中发现内膜厚度和壁切应力之间存在统计学显着相关性。结论-在研究的4条RCA中，壁切应力似乎与内膜厚度无关。
Objective - Low wall shear stress has been implicated in atherogenesis throughout the arterial tree, including the right coronary artery (RCA). The objective of this study was to determine the level of covariation of intimal thickness and wall shear stress in the human RCA.Methods and Results - Postmortem histological measurements of intimal thickness were compared with wall shear stresses calculated from computational flow modeling in 4 human right coronary arteries. A statistically significant correlation between intimal thickness and wall shear stress was found in only 1 of the 4 arteries studied.Conclusion - Wall shear stress does not appear to be related to intimal thickness in the 4 RCAs studied.