Cytokine mRNA in brain tissue from mice that show strain-dependent differences in the severity of lesions induced by systemic infection with Candida albicans yeast.
Cytokine mRNA in brain tissue from mice that show strain-dependent differences in the severity of lesions induced by systemic infection with Candida albicans yeast.
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小鼠脑组织中的细胞因子 mRNA 显示白色念珠菌全身感染引起的病变严重程度存在菌株依赖性差异。
DOI：
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发表时间：
1995
影响因子：
6.4
通讯作者：
A. Fulurija
中科院分区：
文献类型：
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作者：
R. Ashman;E. Bolitho;A. Fulurija
BALB/c和CBA/CaH小鼠对白色念珠菌感染表现出离散的、基因决定的组织反应模式。通过半定量逆转录聚合酶链反应，干扰素(IFN)- γ、白细胞介素(IL)-6和肿瘤坏死因子(TNF)- α在感染后的第1、3和5天很容易在脑组织中被证实，并且在CBA/CaH中的浓度高于BALB/c小鼠。IL-2和-4在两株菌株中均有检测，但时间点不同。真菌负担和组织损伤的严重程度在细胞因子mRNA浓度在病变中增加之前就已经确定，并且酵母菌的清除率在两种小鼠品系中相似。数据表明，将Th1和Th2细胞因子分别与抗性和易感性联系起来的确定性模型，不足以解释亚致死攻击后受感染大脑中细胞因子产生的模式。
BALB/c and CBA/CaH mice show discrete, genetically determined patterns of tissue responses to infection with the yeast Candida albicans. By use of a semiquantitative reverse transcriptase-polymerase chain reaction, interferon (IFN)-gamma, interleukin (IL)-6, and tumor necrosis factor (TNF)-alpha were readily demonstrated in brain tissue on days 1, 3, and 5 after infection and were present in higher concentrations in CBA/CaH than in BALB/c mice. IL-2 and -4 were detected in both strains but at different time points. Both the fungus burden and the severity of the tissue damage become established before mRNA concentrations of the cytokines increase in the lesions, and the rate of clearance of the yeast is similar in both mouse strains. The data indicate that the deterministic model, which correlates Th1 and Th2 cytokines with resistance and susceptibility, respectively, is inadequate to account for the patterns of cytokine production that develop in the infected brain after sublethal challenge.
CD4 T 淋巴细胞响应结核分枝杆菌感染而分泌细胞因子。
DOI：
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发表时间：
1993
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Orme,IM;Roberts,AD;Griffin,JP;Abrams,JS
通讯作者：
Abrams,JS