POPULATION CORRELATES OF PLASMA-FIBRINOGEN AND FACTOR-VII, PUTATIVE CARDIOVASCULAR RISK-FACTORS
POPULATION CORRELATES OF PLASMA-FIBRINOGEN AND FACTOR-VII, PUTATIVE CARDIOVASCULAR RISK-FACTORS
复制标题
DOI：
10.1016/0021-9150(91)90167-2
复制
发表时间：
1991-12-01
期刊：
影响因子：
5.3
通讯作者：
SZKLO, M
中科院分区：
文献类型：
--
作者：
FOLSOM, AR;WU, KK;SZKLO, M
最近的前瞻性研究报道，较高的血浆纤维蛋白原浓度和较高的凝血因子VII活性与心血管疾病的风险较高。为了发现什么样的特征可能会影响纤维蛋白原和因子VII，我们分析了从1986年12月至1989年6月从四个社区获得的12000多名年龄在45-64岁的男性和女性的动脉粥样硬化风险社区研究的数据。黑人纤维蛋白原高于白人，女性纤维蛋白原高于男性;一般来说，随着年龄、吸烟、体型、糖尿病、空腹血清胰岛素、LDL胆固醇、脂蛋白（a）、白细胞计数和绝经而增加，随着乙醇摄入量、体力活动、HDL胆固醇和女性激素使用而减少。因子VII在女性中高于男性，并且在女性中，随年龄增加而增加;在两性中，它随体型、甘油三酯、LDL胆固醇和HDL胆固醇增加而增加，并且随乙醇摄入而减少。这些发现表明，纤维蛋白原和因子VII的升高可能是通过适当的生活方式的改变而改变的。
Recent prospective investigations have reported that higher plasma fibrinogen concentrations and higher factor VII coagulant activity are associated with greater risk of cardiovascular disease. To discover what characteristics may influence fibrinogen and factor VII, we analyzed data from the Atherosclerosis Risk in Communities Study obtained from over 12000 men and women, aged 45-64 years, from four communities in December 1986 to June 1989. Fibrinogen was higher in blacks than whites and in women than men; in general, it increased with age, smoking, body size, diabetes, fasting serum insulin, LDL cholesterol, lipoprotein(a), leukocyte count, and menopause, and it decreased with ethanol intake, physical activity, HDL cholesterol, and female hormone use. Factor VII was higher in women than men and, in women, increased with age; in both sexes, it increased with body size, triglycerides, LDL cholesterol, and HDL cholesterol, and it decreased with ethanol intake. These findings indicate that elevations in fibrinogen and factor VII may be modifiable through appropriate lifestyle changes.