Role of Fas ligand (CD95L) in immune escape: the tumor cell strikes back.
Role of Fas ligand (CD95L) in immune escape: the tumor cell strikes back.
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Fas 配体 (CD95L) 在免疫逃逸中的作用：肿瘤细胞反击。
DOI：
10.4049/jimmunol.158.10.4521
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发表时间：
1997
影响因子：
4.4
通讯作者：
P. Dietrich
中科院分区：
文献类型：
--
作者：
P. Walker;P. Saas;P. Dietrich
最近发现几种不同类型的肿瘤表达功能性Fas配体(FasL)，这可能代表了肿瘤逃逸的另一种机制。然而，这些发现在激活的CTL或NK细胞等强大对手的背景下的体内意义仍有待完全确定。因此，肿瘤细胞和宿主免疫反应之间的潜在相互作用比人们所认为的要复杂得多，它们的阐明将有助于合理设计癌症免疫治疗策略。
Several different tumor types have recently been shown to express functional Fas ligand (FasL), which may represent an additional mechanism of tumor escape. However, the in vivo significance of these findings in the context of potent adversaries such as activated CTL or NK cells remains to be fully established. The potential interactions between tumor cells and the host immune response are thus more complex than previously thought; their elucidation will benefit the rational design of cancer immunotherapy strategies.