Tendons exhibit greater resistance to tissue and molecular-level damage with increasing strain rate during cyclic fatigue.
Tendons exhibit greater resistance to tissue and molecular-level damage with increasing strain rate during cyclic fatigue.
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DOI：
10.1016/j.actbio.2021.07.045
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发表时间：
2021-10-15
影响因子：
9.7
通讯作者：
Weiss JA
中科院分区：
文献类型：
--
作者：
Zitnay JL;Lin AH;Weiss JA
肌肉骨骼软结缔组织通常因重复使用而损伤，但在重复加载过程中对组织结构的机械损伤演变知之甚少。我们研究了大鼠尾腱束蠕变疲劳加载过程中，胶原机械变性作为结构微损伤积累的一种形式对应变速率的依赖性。我们在三种应变速率下循环肌腱，使其相对于其速率相关的抗拉强度达到相同的最大应力。用胶原杂交肽结合荧光定量法测定疲劳过程中胶原变性情况。胶原变性量与肌束蠕变应变显著相关，与循环应变速率无关，支持我们的假设，即组织水平蠕变是由胶原蛋白三螺旋展开引起的。加载速度越快的试样，相对于破坏，其蠕变应变和变性次数越多。尽管在高速率负荷事件中，这种以更快速度增加的损伤能力可能是一种保护措施，但它也可能使这些组织更易受到随后的损伤，并表明一种过度使用损伤发展的机制。这些结果建立在分子水平的胶原变性是拉伸加载过程中肌腱结构损伤的基本机制的证据之上。
Musculoskeletal soft connective tissues are commonly injured due to repetitive use, but the evolution of mechanical damage to the tissue structure during repeated loading is poorly understood. We investigated the strain rate dependence of mechanical denaturation of collagen as a form of structural microdamage accumulation during creep fatigue loading of rat tail tendon fascicles. We cycled tendons at three strain rates to the same maximum stress relative to their rate-dependent tensile strength. Collagen denaturation throughout the fatigue process was measured by fluorescence quantification of collagen hybridizing peptide binding. The amount of collagen denaturation was significantly correlated with fascicle creep strain, independent of the cyclic strain rate, supporting our hypothesis that tissue level creep is caused by collagen triple-helix unfolding. Samples that were loaded faster experienced more creep strain and denaturation as a function of the number of loading cycles relative to failure. Although this increased damage capacity at faster rates may serve as a protective measure during high-rate loading events, it may also predispose these tissues to subsequent injury and indicate a mechanism of overuse injury development. These results build on evidence that molecular-level collagen denaturation is the fundamental mechanism of structural damage to tendons during tensile loading.
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DOI：
10.1002/jor.20722
发表时间：
2009-02
期刊：
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
影响因子：
--
作者：
Fung DT;Wang VM;Laudier DM;Shine JH;Basta-Pljakic J;Jepsen KJ;Schaffler MB;Flatow EL
通讯作者：
Flatow EL
影响因子：
9.7
作者：
Herod, Tyler W.;Chambers, Neil C.;Veres, Samuel P.
通讯作者：
Veres, Samuel P.
DOI：
10.1016/j.cma.2011.11.015
发表时间：
2012-01-01
影响因子：
7.2
作者：
Balzani, Daniel;Brinkhues, Sarah;Holzapfel, Gerhard A.
通讯作者：
Holzapfel, Gerhard A.
DOI：
10.1097/00005768-199908000-00015
发表时间：
1999-08-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Almeida, SA;Williams, KM;Brodine, SK
通讯作者：
Brodine, SK
影响因子：
4.6
作者：
Keuler, Emily M.;Loegering, Isaac F.;Thelen, Darryl G.
通讯作者：
Thelen, Darryl G.