The Regulation of Cerebral Spinal Fluid Flow and Its Relevance to the Glymphatic System.
The Regulation of Cerebral Spinal Fluid Flow and Its Relevance to the Glymphatic System.
复制标题
大脑脊髓流动的调节及其与淋巴系统的相关性。
DOI：
10.1007/s11910-020-01077-9
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发表时间：
2020-10-19
影响因子：
5.6
通讯作者：
Claassen DO
中科院分区：
文献类型：
--
作者：
McKnight CD;Rouleau RM;Donahue MJ;Claassen DO
The glymphatic system is a relatively new concept that has been associated with regulation of cerebrospinal fluid (CSF), as well as brain waste clearance. Novel techniques to study glymphatic dysfunction have in turn prompted new concepts pertaining to brain physiology and have reviewed interest in understanding the underlying elements of neurological disease. This review incorporates a radiologic and human imaging perspective that focuses on contemporary understanding of the regulation of CSF flow, expanding the putative clinical relevance of this system and the relationships between CSF flow and glymphatic function. MR imaging studies, especially those that employ intrathecal gadolinium contrast, have identified potentially new pathways that may regulate CSF production, absorption, and clearance. These studies particularly emphasize putative mechanisms for brain waste clearance. Glymphatic flow around cranial nerves and within the subarachnoid region may be under-investigated, and could be related to various pathophysiologic processes in neurodegeneration. We emphasize several clinical exemplars of CSF clearance that point to the interaction between the epidural space, perivascular spaces, and the neurovascular unit. Given insufficient understanding of these interactions, further studies should focus on techniques addressing glymphatic functionality and potentially linking this system to neurological disease.
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影响因子：
1.4
作者：
Lüdemann, W;von Rautenfeld, DB;Brinker, T
通讯作者：
Brinker, T
影响因子：
7.7
作者：
Absinta M;Ha SK;Nair G;Sati P;Luciano NJ;Palisoc M;Louveau A;Zaghloul KA;Pittaluga S;Kipnis J;Reich DS
通讯作者：
Reich DS
DOI：
10.1073/pnas.91.26.12599
发表时间：
1994-12-20
影响因子：
11.1
作者：
PREHN, JHM;BINDOKAS, VP;MILLER, RJ
通讯作者：
MILLER, RJ
DOI：
10.1111/j.1365-2990.1994.tb01008.x
发表时间：
1994-12-01
影响因子：
5
作者：
LOWHAGEN, P;JOHANSSON, BB;NORDBORG, C
通讯作者：
NORDBORG, C
影响因子：
17.1
作者：
Iliff JJ;Wang M;Liao Y;Plogg BA;Peng W;Gundersen GA;Benveniste H;Vates GE;Deane R;Goldman SA;Nagelhus EA;Nedergaard M
通讯作者：
Nedergaard M