Dietary fish oil modestly attenuates the effect of age on diastolic function but has no effect on memory or brain inflammation in aged rats.
Dietary fish oil modestly attenuates the effect of age on diastolic function but has no effect on memory or brain inflammation in aged rats.
复制标题
膳食鱼油可适度减弱年龄对舒张功能的影响，但对老年大鼠的记忆或脑部炎症没有影响。
DOI：
10.1093/gerona/glr017
复制
发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Nicolle,MichelleM
中科院分区：
文献类型：
--
作者：
Sergeant,Susan;McQuail,JosephA;Riddle,DavidR;Chilton,FloydH;Ortmeier,StevenB;Jessup,JewellA;Groban,Leanne;Nicolle,MichelleM
鱼油（FO）在心血管疾病患者中介导了许多心脏保护益处。然而，在没有心血管疾病的情况下，FO对心脏结构和功能的影响尚不清楚。此外，目前尚不清楚减轻年龄相关性心功能障碍的有效给药策略是否也能有效限制认知功能障碍。因此，我们确定了在老年大鼠中补充FO 4个月是否会减轻年龄相关的心功能障碍，同时防止在该人群中通常观察到的认知能力下降。结果表明，在生命后期开始的FO通过减弱与年龄相关的充盈压、后壁厚度和间质胶原的增加而不减轻与年龄相关的记忆缺陷或脑炎症的增加，以小但积极的方式改变舒张功能。这些数据提出了一种可能性，即为了保护心脏和大脑而补充FO可能需要在生命周期的早期发生。
Fish oil (FO) mediates a number of cardioprotective benefits in patients with cardiovascular disease. In the absence of cardiovascular disease, however, the effects of FO on cardiac structure and function are not clear. In addition, it is not known if an effective dosing strategy for attenuating age-related cardiac dysfunction is also effective at limiting cognitive dysfunction. Therefore, we determined if 4 months of FO supplementation in aged rats would lessen age-related cardiac dysfunction while concomitantly preventing the cognitive decline that is normally observed in this population. The results indicate that FO initiated late in life modifies diastolic function in a small but positive way by attenuating the age-related increases in filling pressure, posterior wall thickness, and interstitial collagen without mitigating age-related deficits in memory or increases in brain inflammation. These data raise the possibility that FO supplementation for purposes of cardiac and brain protection may need to occur earlier in the life span.