Medication tolerance and augmentation in restless legs syndrome: The need for drug class rotation
Medication tolerance and augmentation in restless legs syndrome: The need for drug class rotation
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DOI：
10.1111/j.1525-1497.2006.00593_1.x
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发表时间：
2006-12-01
影响因子：
5.7
通讯作者：
Deeley, Cheryl
中科院分区：
文献类型：
--
作者：
Kurlan, Roger;Richard, Irene Hegeman;Deeley, Cheryl
不宁腿综合症(RLS)是一种常见的疾病，其特征是想要移动双腿的冲动令人不快，通常发生在晚上，可能会干扰睡眠。最常用于治疗RLS的药物包括多巴胺能药物(左旋多巴、多巴胺激动剂)、苯二氮卓类药物和麻醉性止痛药。我们报告了2名RLS患者的病例，他们表现出耐受性(随着时间的推移反应下降)和增强(由于正在进行的治疗而症状恶化)的问题，这可能会使RLS的药物治疗复杂化。我们讨论了RLS的优化管理，并提出了克服容错和增强的策略，如不同类别的代理之间的轮换方法。
Restless legs syndrome (RLS) is a common condition characterized by an unpleasant urge to move the legs that usually occurs at night and may interfere with sleep. The medications used most commonly to treat RLS include dopaminergic drugs (levodopa, dopamine agonists), benzodiazepines, and narcotic analgesics. We report the cases of 2 patients with RLS who illustrate the problems of tolerance (declining response over time) and augmentation (a worsening of symptoms due to ongoing treatment) that can complicate the pharmacotherapy of RLS. We discuss the optimal management of RLS and propose strategies to overcome tolerance and augmentation such as a rotational approach among agents from different classes.