Occupational exposure to meat and risk of lymphoma: A multicenter case-control study from Europe
Occupational exposure to meat and risk of lymphoma: A multicenter case-control study from Europe
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DOI：
10.1002/ijc.22994
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发表时间：
2007-12-15
影响因子：
6.4
通讯作者：
Boffetta, Paolo
中科院分区：
文献类型：
--
作者：
Moore, Tina;Brennan, Paul;Boffetta, Paolo
几项研究表明，在没有确凿证据的情况下，接触肉类的工人患淋巴瘤的风险会增加。我们在1998-2004年间在捷克共和国、法国、德国、爱尔兰、意大利和西班牙进行了一项多中心病例对照研究，包括2,007例非霍奇金淋巴瘤、339例霍奇金淋巴瘤和2,462例对照。我们收集了详细的职业史信息，并通过问卷的专家评估评估了一般肉类和几种肉类的暴露情况。非霍奇金淋巴瘤发生的OR值为1.18(95%可信区间0.95~1.46)，暴露于牛肉为1.22(95%可信区间0.90~1.67)，暴露于鸡肉为1.19(95%可信区间0.91~1.55)。接触时间较长的工人的OR值更高。接触牛肉工人的危险性增加主要表现为弥漫性大B细胞淋巴瘤(OR 1.49，95%CI 0.96~2.33)、慢性淋巴细胞白血病(OR 1.35，95%CI 0.78~2.34)和多发性骨髓瘤(OR 1.40，95%CI 0.67~2.94)。后两种类型与接触鸡肉有关(OR1.55，95%CI 1.01~2.37；OR2.05，95%CI 1.14~3.69)。滤泡性淋巴瘤和T细胞淋巴瘤以及霍奇金淋巴瘤的风险没有任何增加。职业接触肉类似乎不是淋巴瘤的重要危险因素，尽管不能排除特定类型的非霍奇金淋巴瘤风险增加。(C)2007年Wiley-Liss，Inc.
Several studies have suggested an increased risk of lymphoma among workers exposed to meat, without conclusive evidence. We conducted a multicenter case-control study during 1998-2004 in the Czech Republic, France, Germany, Ireland, Italy and Spain, including 2,007 cases of non-Hodgkin lymphoma, 339 cases of Hodgkin lymphoma and 2,462 controls. We collected detailed information on occupational history and assessed exposure to meat in general and several types of meat via expert assessment of the questionnaires. The odds ratio (OR) of non-Hodgkin lymphoma for ever occupational exposure to meat was 1.18 (95% confidence interval [CI] 0.95-1.46), that for exposure to beef meat was 1.22 (95% CI 0.90-1.67), and that for exposure to chicken meat was 1.19 (95% CI 0.91-1.55). The ORs were higher among workers with longer duration of exposure. An increased risk among workers exposed to beef meat was mainly apparent for diffuse large B-cell lymphoma (OR 1.49, 95%CI 0.96-2.33), chronic lymphocytic leukemia (OR 1.35, 95% CI 0.78-2.34) and multiple myeloma (OR 1.40, 95%CI 0.67-2.94). The latter 2 types were also associated with exposure to chicken meat (OR 1.55, 95% CI 1.01-2.37, and OR 2.05, 95%CI 1.14-3.69). Follicular lymphoma and T-cell lymphoma, as well as Hodgkin lymphoma did not show any increase in risk. Occupational exposure to meat does not appear to represent an important risk factor of lymphoma, although an increased risk of specific types of non-Hodgkin lymphoma cannot be excluded. (c) 2007 Wiley-Liss, Inc.