APOLIPOPROTEIN(A) ALLELES DETERMINE LIPOPROTEIN(A) PARTICLE DENSITY AND CONCENTRATION IN PLASMA
APOLIPOPROTEIN(A) ALLELES DETERMINE LIPOPROTEIN(A) PARTICLE DENSITY AND CONCENTRATION IN PLASMA
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DOI：
10.1161/01.atv.12.3.302
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发表时间：
1992-03-01
期刊：
影响因子：
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通讯作者：
UTERMANN, G
中科院分区：
文献类型：
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作者：
KRAFT, HG;SANDHOLZER, C;UTERMANN, G
本文用密度梯度超离心法测定了29例已知载脂蛋白（a）表型的正常人血浆中脂蛋白（a）脂蛋白（Lp[a]）和遗传载脂蛋白（a）（apo[a]）亚型的分布。 Lp（a）的密度与apo（a）亚型的大小直接相关，范围从LpF表型的1.043 μ g/ml到LpS 4表型的1.114 μ g/ml。 杂合子有两个不同的Lp（a）颗粒，每个颗粒在血浆中含有各自的亚型之一。 在各杂合子中，轻脂蛋白（a）的浓度均高于高脂蛋白（a）的浓度。 这些数据表明，载脂蛋白（a）等位基因决定了密度和代谢，从而也决定了血浆中Lp（a）颗粒的浓度。
The distribution of Lp(a) lipoprotein (Lp[a]) and genetic apolipoprotein(a) (apo[a]) isoforms in plasma samples from 29 healthy normolipidemic subjects of known apo(a) phenotype was evaluated by density gradient ultracentrifugation. The density of Lp(a) was directly related to the size of the apo(a) isoform, ranging from 1.043 g/ml for the LpF phenotype to 1.114 g/ml for the LpS4 phenotype. Heterozygotes had two distinct Lp(a) particles, each containing one of the respective isoforms in plasma. In each heterozygote, the concentration of the lighter Lp(a) species was higher than that of the denser Lp(a) population. These data suggest that apo(a) alleles determine the density and the metabolism and thereby also the concentrations of Lp(a) particles in plasma.