Is there a correlation between organochlorine compounds and undescended testes?
Is there a correlation between organochlorine compounds and undescended testes?
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DOI：
10.1055/s-2008-1072381
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发表时间：
2000-10-01
影响因子：
1.8
通讯作者：
Waag, KL
中科院分区：
文献类型：
--
作者：
Hosie, S;Loff, S;Waag, KL
一些农药和合成化学品被认为是激素调节剂，通常具有雌激素活性（异种雌激素）。它们是持久的，并在脂肪组织中积累。我们研究的目的是解决这样一个问题，即在接受外科手术的儿童的脂肪组织中是否会发现这种化合物的选择，以及从患有或没有隐睾的患者中获得的值是否存在差异。采用高分辨率气相色谱和质谱法对48例患者（其中18例为隐睾患者）的脂肪样本进行滴滴涕及其代谢物、多氯联苯（PCB）、毒虫、六氯环己烷（HCH）、氯化环二烯和氯化苯的检测。我们在每个病人身上都发现了所有物质的积累。统计分析显示，七氯环氧化物（HCE）和六氯苯（HCB）两种化合物在隐睾组和对照组之间差异极显著，在隐睾组患者中升高。由于这一实体的病因不明，在大多数情况下，产前暴露于外源性雌激素是一个有吸引力的和合理的假设。为了证实这一点，必须在进一步的研究中回答一些问题：在特定发育时期接触异种雌激素的影响，其他已证实或怀疑具有激素活性的物质的可能作用，这些化合物的潜在协同作用以及个体易感性的差异。
Some pesticides and synthetic chemicals are known to act as hormonal modulators, often possessing oestrogenic activity (xenooestrogens). They are persistent and accumulate in fatty tissue. Aim of our study is to address the question, whether a selection of such compounds is to be found in the fatty tissue of children undergoing surgical procedures and whether there are differences in values obtained from patients with or without undescended testes. Fat samples of 48 patients, 18 of whom had undescended testes, were examined by high-resolution gas chromatography and mass spectrometry for DDT and metabolites, polychlorinated biphenyls (PCB), toxaphenes, hexachlorocyclohexane (HCH), chlorinated cyclodienes and chlorinated benzenes. We were able to find accumulation of all substances in every patient. Statistical analysis revealed a highly significant difference between patients from the control group and those from the undescended testes group for two compounds, namely heptachloroepoxide (HCE) and hexachlorobenzene (HCB), increased values being found in the patients with undescended testes. Since the aetiology of this entity is unknown in most of the cases, prenatal exposure to exogenous oestrogens is an attractive and plausible hypothesis. In order to confirm this, some questions will have to be answered in further studies: effect of exposure to xenooestrogens during a specific period of development, probable role of other substances with proven or suspected hormonal activity, potential synergism of such compounds and differences in individual susceptibility.