Investigating causal relationships between Body Mass Index and risk of atopic dermatitis: a Mendelian randomization analysis
Investigating causal relationships between Body Mass Index and risk of atopic dermatitis: a Mendelian randomization analysis
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DOI：
10.1038/s41598-020-72301-2
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发表时间：
2020-09-17
影响因子：
4.6
通讯作者：
Chambers, John C.
中科院分区：
文献类型：
--
作者：
Yew, Yik Weng;Loh, Marie;Chambers, John C.
人群研究表明，特应性皮炎（AD）与肥胖风险增加有关，但这两种疾病之间的因果关系仍有待确定。因此，我们使用孟德尔随机化（MR）来评估肥胖和AD是否存在因果关系。我们使用从体重指数（BMI）和AD的全基因组关联研究中提取的汇总统计量。在两个方向上进行MR分析，以确定BMI和AD之间的因果关系方向。我们发现，遗传决定的肥胖增加与AD风险增加相关（BMI每增加1个单位，AD的比值比为1.08 [95%CI 1.01 - 1.14; p=0.015]）。相反，遗传决定的AD风险增加与较高的BMI无关（基于遗传信息归因于AD的BMI变化：0.00; 95% CI-0.02至0.02; p=0.862）。没有证据表明这些遗传分析受到水平多效性的干扰。我们的研究结果表明，AD与肥胖的关联可能反映了肥胖在AD发展中的因果作用。我们的发现增强了对AD病因学的理解，并为评价肥胖促进AD的机制途径的实验研究奠定了基础。
Population studies suggest that atopic dermatitis (AD) is associated with an increased risk of obesity, however a causal relationship between these two conditions remains to be established. We therefore use Mendelian randomization (MR) to evaluate whether obesity and AD are causally interlinked. We used summary statistics extracted from genome wide association studies of Body Mass Index (BMI) and AD. MR analysis was performed in both directions to establish the direction of causality between BMI and AD. We find that genetically determined increase in adiposity is associated with increased risk of AD (odds ratio of AD 1.08 [95% CI 1.01 to 1.14; p=0.015] per unit increase in BMI). Conversely, genetically determined increased risk of AD is not associated with a higher BMI (change in BMI attributable to AD based on genetic information: 0.00; 95% CI-0.02 to 0.02; p=0.862). There was no evidence for confounding of these genetic analyses by horizontal pleiotropy. Our results indicate that the association of AD with obesity is likely to reflect a causal role for adiposity in the development of AD. Our findings enhance understanding of the etiology of AD, and the basis for experimental studies to evaluate the mechanistic pathways by which adiposity promotes AD.