Effect of 1-hexylcarbamoyl-5-fluorouracil on spontaneous mammary adenocarcinoma of mice.
Effect of 1-hexylcarbamoyl-5-fluorouracil on spontaneous mammary adenocarcinoma of mice.
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1-己基氨基甲酰基-5-氟尿嘧啶对小鼠自发性乳腺癌的影响。
DOI：
10.20772/cancersci1959.71.5_724
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
K. Kuretani
中科院分区：
文献类型：
--
作者：
R. Tokuzen;M. Iigo;A. Hoshi;K. Kuretani
在 SHN 小鼠的自发性乳腺癌（一种原生肿瘤系统）中检查了 1-己基氨基甲酰基-5-氟尿嘧啶 (HCFU) 在各种长期口服给药方案中的抗肿瘤活性。在对照组中，手术干预后局部复发的平均时间和平均寿命分别为 21 天和 48 天。每2或3周口服HCFU 200约300mg/kg/天，每周3次，连续5天，对腺癌显着有效。最佳方案是 HCFU 给药 20 次，剂量为 300 mg/kg/天，每周 3 次。术后平均局部复发时间延长至200%，术后平均生存率也延长至150%。肿瘤生长较慢，尸检时发现 HCFU 抑制了肺转移。 HCFU延缓局部复发和延长寿命的效果受给药方案影响较小。
The antitumor activity of 1-hexylcarbamoyl-5-fluorouracil (HCFU) in various schedules of long-term oral administration was examined in spontaneous mammary adenocarcinoma of SHN mice, an autochthonous tumor system. In the control group, the average time to local recurrence and average longevity after surgical intervention were 21 and 48 days, respectively. Oral administration of HCFU at 200 approximately 300 mg/kg/day, 3 times a week for 5 consecutive days every 2 or 3 weeks was markedly effective against the adenocarcinoma. The optimal schedule was 20 administrations of HCFU at 300 mg/kg/day, 3 times a week. The average time to local recurrence after the operation was increased to 200% and average postoperative survival was also prolonged to 150%. Growth of the tumors was slower and lung metastases at autopsy were found to be suppressed by HCFU. The effect of HCFU in delaying local recurrence and prolonging longevity was slightly affected by the schedule of administration.