Family history of colorectal cancer in a Sweden county.
Family history of colorectal cancer in a Sweden county.
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DOI：
10.1023/a:1025734200635
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发表时间：
2003-01-01
期刊：
影响因子：
2.2
通讯作者：
Lindblom, Annika
中科院分区：
文献类型：
--
作者：
Olsson, Louise;Lindblom, Annika
遗传性非息肉病性结直肠癌(HNPCC)和家族性腺瘤性息肉病(FAP)是众所周知的高危癌症综合征。遗传性结直肠癌(HCRC)至少有三个亲属患有结直肠癌，遗传模式占优势，但没有具体说明发病年龄，两个近亲患有结直肠癌(TCR)是已知的其他形式的家族聚集性，具有更高的患病风险。家族性结直肠癌总负担的频率还不是很清楚。因此，我们调查了瑞典瓦斯特曼兰县400/411(97%)符合条件的新近诊断为结直肠癌的患者在3年期间的家族病史。记录或死亡证明证实了亲属的诊断。5例(1.2%，95%CI 0.15~2.2)诊断为HNPCC，8例(1.9%，95%CI 0.6~3.2)诊断为HCRC，34例(8.3%，95%CI 5.6~11.0)诊断为TCR。总共有47名患者(11.4%，95%可信区间8.3-14.5)被发现有贡献的家族背景。因此，这意味着，每九名结直肠癌患者中，亲属患这种疾病的风险就会高度或中度增加。我们的结论是，仅通过家族史确定的个人频率较低，因此建立监测方案是可行的。
Hereditary nonpolyposis colorectal cancer (HNPCC) and familial adenomatosis polyposis (FAP) are well-known high-risk cancer syndromes. Hereditary colorectal cancer (HCRC) with at least three relatives with colorectal cancer and a dominant pattern of inheritance but with no specifications for age at onset and two close relatives with colorectal cancer (TCR) are other forms of familial clustering known to carry an increased risk of the disease. The frequency of the total burden of familial colorectal cancer is not well known. We therefore investigated the family history of 400/411 (97%) eligible patients with recently diagnosed colorectal cancer in Vastmanland county, Sweden, during a 3-year period. Records or death certificates confirmed the diagnoses of relatives. Five patients (1.2%, 95% CI 0.15-2.2) were diagnosed as having HNPCC, eight (1.9%, 95% CI 0.6-3.2) as having HCRC and thirty-four (8.3%, 95% CI 5.6-11.0) were identified as having TCR. In total, 47 patients (11.4%, 95% CI 8.3-14.5) were found to have a contributing familial background. The implication is thus that every ninth patient with colorectal cancer represents a highly or intermediately increased risk of the disease among relatives. We conclude that the low frequency of individuals identified by family history alone makes the establishment of surveillance programs feasible.