Interferons and natural killer cells.
Interferons and natural killer cells.
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干扰素和自然杀伤细胞。
DOI：
10.1093/oxfordjournals.bmb.a072018
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发表时间：
1985
影响因子：
6.7
通讯作者：
Bloom,BR
中科院分区：
文献类型：
--
作者：
Rager-Zisman,B;Bloom,BR
干扰素（ifn）是一个由至少16种不同的蛋白质和糖蛋白组成的家族，它们在微量的情况下就能发挥深远的生物学作用。IFNα、IFNβ和IFNγ都具有保护培养细胞免受病毒感染的共同能力。此外，它们还具有广泛的生物调控功能，包括细胞增殖、形态、分化、酶诱导、细胞表面抗原表达和功能。此外，ifn，特别是由T细胞产生的IFNγ是有效的免疫调节分子，可以影响抗体形成、抗原呈递、细胞介导的免疫和巨噬细胞活化。特别令人感兴趣的是一种免疫机制，通过这种机制，非免疫淋巴细胞，自然杀伤（NK）细胞，可以选择性地在体外裂解一些肿瘤、胚胎和病毒感染的靶细胞。效应细胞是非t细胞，非b细胞，其细胞毒性潜能主要由ifn调节。易感靶细胞的裂解似乎是通过囊泡脱粒和细胞毒性因子的释放过程介导的。随着克隆IFN的可用性，应该有可能评估IFN Nk细胞系统在预防或限制病毒感染以及抑制肿瘤生长和转移方面所起的作用。
The interferons (IFNs) are a family of at least 16 distinct proteins and glycoproteins that exert profound biological effects in minute amounts. IFNα, IFNβ and IFNγ all have in common the ability to protect cultured cells against infection by viruses. In addition, they have a wide range of biological regulatory fuctions, including cellular proliferation, morphology, differatiation, enzyme induction, cell-surface antigen expression and function. Furthermore, the IFNs, particularly IFNγ produced by T cells are potent immunoregulatory molecules, which can affect antibody formation, antigen presentation, cell-mediated immunity and macrophage activation. Of particular interest is an immunological mechanism by which non-immunized lymphocytes, natural killer (NK) cells, can selectively lyse some tumour, embryonal and virus-infected target cells in vitro. The effector cells are non-T, non-B cells whose cytotoxic potential is regualted primilarily by IFNs. Lysis of susceptible target cells appears to be mediated by a process of vesicular degranulation and release of cytotoxic factors. With the availability of cloned IFNs, it should be possible to assess the role played by the IFN Nk cell system in preventing or restricting viral infection, and inhibiting tumour growth and metastasis.