Disruption of the fifth melanocortin receptor alters the urinary excretion of aggression-modifying pheromones in male house mice
Disruption of the fifth melanocortin receptor alters the urinary excretion of aggression-modifying pheromones in male house mice
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DOI：
10.1093/chemse/27.1.91
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发表时间：
2002-01-01
期刊：
影响因子：
3.5
通讯作者：
Lepri, JJ
中科院分区：
文献类型：
--
作者：
Caldwell, HK;Lepri, JJ
The preputial glands of house mice express the gene for the fifth melanocortin receptor (MC5-R) and are a primary source of urinary pheromones involved in inter-male aggression. A 'resident-intruder' behavioral model was used to compare the responses of resident males to urine from mice with an engineered disruption of the fifth melanocortin receptor (MC5-RKO) with residents' responses to urine from wild-type mice (WT). Each type of urine was presented in combination with a castrated intruder male to provide the appropriate biological context. Resident males responded with a longer latency to bite when the urine was from gonadally intact WT males compared with urine from MC5-RKO mice. These results are consistent with the hypothesis that activation of the fifth melanocortin receptor in the preputial glands of male house mice causes excretion of urinary pheromones that delay aggressive responses by other males.
