SEXUALLY DIMORPHIC STERILITY PHENOTYPES IN HOXA10-DEFICIENT MICE
SEXUALLY DIMORPHIC STERILITY PHENOTYPES IN HOXA10-DEFICIENT MICE
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DOI：
10.1038/374460a0
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发表时间：
1995-03-30
期刊：
影响因子：
64.8
通讯作者：
MAAS, R
中科院分区：
文献类型：
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作者：
SATOKATA, I;BENSON, G;MAAS, R
腹型B(AbdB)基因构成了一个独特的同源异型盒基因亚家族，具有表达的后部结构域(1，2)，包括果蝇的生殖器成像盘和脊椎动物发育中的泌尿生殖系统(3，4)。我们已经在小鼠身上突变了AbdB基因Hoxa10，我们在这里报告了纯合子完全存活，并显示出腰椎的前向同源转化。所有男性纯合子都表现为双侧隐睾症，导致严重的精子发生缺陷，并随着年龄的增长而增加不育率。雌性纯合子正常排卵，但约80%是不育的，因为胚胎在阴蒂后2.5-3.5天死亡。这与母体Hoxa10在输卵管远端和子宫上皮中的表达在空间和时间上是一致的。这些结果表明AbdBHox基因在男性和女性生育能力中的作用，并表明母体Hoxa10需要调节一个影响植入前胚胎活力的因子的表达。
THE Abdominal B (AbdB) genes constitute a distinct subfamily of homeobox genes that exhibit posterior domains of expression(1,2), including the genital imaginal disc in Drosophila and the developing urogenital system in vertebrates(3,4). We have mutated the AbdB gene Hoxa10 in mice, We report here that homozygotes are fully viable and show an anterior homeotic transformation of lumbar vertebrae. All male homozygotes manifest bilateral cryptorchidism resulting in severe defects in spermatogenesis and increasing sterility with age. Female homozygotes ovulate normally, but about 80% are sterile because of death of embryos between days 2.5 and 3.5 post coitum. This coincides spatially and temporally with expression of maternal Hoxa10 in distal oviductal and uterine epithelium. These results indicate a role for AbdB Hox genes in male and female fertility and suggest that maternal Hoxa10 is required to regulate the expression of a factor that affects the viability of preimplantation embryos.