Virosaines A and B, two new birdcage-shaped Securinega alkaloids with an unprecedented skeleton from Flueggea virosa.
Virosaines A and B, two new birdcage-shaped Securinega alkaloids with an unprecedented skeleton from Flueggea virosa.
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DOI：
10.1021/ol301184j
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发表时间：
2012-05
期刊：
影响因子：
5.2
通讯作者：
Bingxin Zhao;Ying Wang;Dong-Mei Zhang;Xiao‐Jun Huang;Liangliang Bai;Yan Yan-Yan;Jia-Mei Chen;T. Lu-
中科院分区：
文献类型：
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作者：
Bingxin Zhao;Ying Wang;Dong-Mei Zhang;Xiao‐Jun Huang;Liangliang Bai;Yan Yan-Yan;Jia-Mei Chen;T. Lu-
本文报道了两个新的叶下珠生物碱，即叶下珠生物碱A（1）和B（2）。通过核磁共振、X-射线衍射和圆二色性分析确定了化合物的结构和绝对构型。化合物1和2代表了第一个带有7-氧杂-1-氮杂双环[3.2.1]辛烷环系统的一叶碱生物碱的例子，其合理的生物遗传途径也被提出。
Two new Securinega alkaloids, virosaines A (1) and B (2), were isolated from the twigs and leaves of Flueggea virosa. The structures and absolute configurations were elucidated by means of NMR, X-ray diffraction, and CD analyses. Compounds 1 and 2 represent the first examples of Securinega alkaloids bearing a 7-oxa-1-azabicyclo[3.2.1]octane ring system, whose plausible biogenetic pathways were also proposed.