Morphologic phenotyping with MR microscopy: The visible mouse

Morphologic phenotyping with MR microscopy: The visible mouse
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DOI:
10.1148/radiol.2223010531
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发表时间:
2002-03-01
期刊:
影响因子:
19.7
通讯作者:
Hedlund, LW
Hedlund, LW
中科院分区:
医学1区
文献类型:
--
作者:
Johnson, GA;Cofer, GP;Hedlund, LW

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通过使用磁共振显微镜证明了一种快速形态学表型分析的方法。整个固定的 C57BL/6J 小鼠以 110-mum 各向同性分辨率成像;完整样本的有限体积,各向同性分辨率为 50 微米;和分离的器官,各向同性分辨率为 25-mum。将三维成像技术应用于尿酸酶基因敲除小鼠,展示了形态学表型的评估方法。 (C) 北美放射学会,2002 年。
A method for rapid morphologic phenotyping is demonstrated by using magnetic resonance microscopy. Whole fixed C57BL/6J mice were imaged at 110-mum isotropic resolution; limited volumes of the intact specimen, at 50-mum isotropic resolution; and isolated organs, at 25-mum isotropic resolution. The three-dimensional imaging technique was applied to uricase knockout mice to demonstrate the method for the evaluation of morphologic phenotype. (C) RSNA, 2002.