Hepatitis B core-related antigen assay is useful for monitoring the antiviral effects of nucleoside analogue therapy
Hepatitis B core-related antigen assay is useful for monitoring the antiviral effects of nucleoside analogue therapy
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DOI：
10.1159/000122592
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发表时间：
2008-01-01
期刊：
影响因子：
4.6
通讯作者：
Maki, Noboru
中科院分区：
文献类型：
--
作者：
Tanaka, Eiji;Matsumoto, Akihiro;Maki, Noboru
目的：本文综述了B型肝炎病毒核心相关抗原（HBcrAg）检测在拉米夫定抗病毒疗效监测中的临床意义。研究方法：HBcrAg检测使用识别这两种变性抗原的共同表位的单克隆抗体同时测量B核心（HBc）和e（HBe）抗原的血清水平。结果如下：虽然血清HBcrAg水平与自然病程中的B肝炎病毒（HBV）DNA水平呈线性相关，但在拉米夫定给药后，HBcrAg的下降明显慢于HBV DNA。我们分析了HBV DNA和HBcrAg水平预测拉米夫定耐药发生的临床意义。HBV DNA检测可能有助于识别拉米夫定耐药高危患者，HBcrAg检测可能有助于检测耐药低风险患者。HBcrAg的测量也被发现是一个有用的预测因素，在停止拉米夫定给药后肝炎的再激活。结论：HBcrAg检测确实可用于监测拉米夫定的抗病毒效果，我们建议将其作为反映肝细胞中HBV共价闭合环状DNA含量的血清标志物。版权所有（c）2008 S. Karger AG，巴塞尔。
Objective: The clinical significance of the hepatitis B virus core-related antigen (HBcrAg) assay in monitoring the antiviral effects of lamivudine is reviewed. Methods: The HBcrAg assay simultaneously measured serum levels of hepatitis B core (HBc) and e ( HBe) antigens using monoclonal antibodies which recognize common epitopes of these two denatured antigens. Results: Although serum HBcrAg levels correlated linearly with those of hepatitis B virus (HBV) DNA in natural course, the decrease in HBcrAg was significantly slower than in HBV DNA after initiation of lamivudine administration. We analyzed the clinical significance of HBV DNA and HBcrAg levels to predict the occurrence of lamivudine resistance. HBV DNA measurement may be useful to identify patients who are at high risk of developing lamivudine resistance, and HBcrAg measurement may help to detect patients who are at low risk of drug resistance. The measurement of HBcrAg was also found to be a useful prognosticator for reactivation of hepatitis after cessation of lamivudine administration. Conclusion: The HBcrAg assay is indeed useful for monitoring the antiviral effects of lamivudine, and wepropose that it be adopted as a serum marker which reflects the amount of HBV covalently closed circular DNA in hepatocytes. Copyright (c) 2008 S. Karger AG, Basel.