Growth of Chlamydia pneumoniae induces cytokine production and expression of CD14 in a human monocytic cell line
Growth of Chlamydia pneumoniae induces cytokine production and expression of CD14 in a human monocytic cell line
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DOI：
10.1128/iai.64.11.4872-4875.1996
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发表时间：
1996-11-01
影响因子：
3.1
通讯作者：
Essig, A
中科院分区：
文献类型：
--
作者：
Heinemann, M;Susa, M;Essig, A
肺炎衣原体能够在人单核细胞系 Mono Mac 6 中存活并繁殖，肺炎衣原体的生长诱导肿瘤坏死因子 α、白细胞介素 1 β 和白细胞介素 6 的产生，以及以时间依赖性方式上调 CD14 分子。单核细胞的感染和促炎细胞因子反应可能在肺炎衣原体发病机制中很重要。
Chlamydia pneumoniae was able to survive and to multiply in the human monocytic cell line Mono Mac 6, Growth of C. pneumoniae induced production of tumor necrosis factor alpha, interleukin 1 beta, and interleukin 6, as well as up-regulation of the CD14 molecule in a time-dependent manner, Infection of monocytic cells and a proinflammatory cytokine response may be important in C. pneumoniae pathogenesis.