Creatine Kinase BB Isoenzyme Blood Levels in Trauma Patients With Suspected Mild Traumatic Brain Injury
Creatine Kinase BB Isoenzyme Blood Levels in Trauma Patients With Suspected Mild Traumatic Brain Injury
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DOI：
10.7205/milmed-d-02-4708
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发表时间：
2009-06-01
影响因子：
1.2
通讯作者：
Lewis, Paul C.
中科院分区：
文献类型：
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作者：
Carr, Marcus E., Jr.;Masullo, Lawrence N.;Lewis, Paul C.
这项初步研究旨在确定肌酸激酶同工酶BB（CK-BB）水平是否可以作为轻度TBI（mTBI）损伤严重程度的生物标志物。这是一项对2007年3月至8月间在摩苏尔的一家战斗支援医院就诊的64名疑似mTBI士兵的回顾性研究。64份样本中有4份CK-BB阳性。1例严重创伤患者CK-BB阴性。这产生了11%的灵敏度和97%的特异性。军事急性脑震荡评估（MACE）评分也没有反映受伤的程度。尽管本研究中CK-BB的低灵敏度不支持其用作疑似mTBI的早期标志物，但鉴于样本量小和运输过程中同工酶降解的可能性，结果并不确定。虽然有限，但收集的MACE评分数据需要额外评价该指标是否具有临床相关性。
This pilot study sought to determine if creatine kinase isoenzyme BB (CK-BB) levels might serve as a biological marker of injury severity in mild TBI (mTBI). This was a retrospective study of 64 soldiers with suspected mTBI seen in a combat support hospital in Mosul between March and August of 2007. Four of the 64 total samples were positive for CK-BB. One major trauma patient had a negative CK-BB. This yields a sensitivity of 11% and a specificity of 97%. Military Acute Concussion Evaluation (MACE) scores collected also did not appear to reflect extent of injury. Although the low sensitivity of CK-BB from this study does not support its use as an early marker of suspected mTBI, the result is not conclusive given the small sample and the possibility of isoenzyme degradation during transport. Although limited, the data collected on MACE scores warrant additional evaluation of whether this measure is clinically relevant.