Determine the myocardial T2* cut-off value in thalassemia using gaussian mixtures models
Determine the myocardial T2* cut-off value in thalassemia using gaussian mixtures models
复制标题
使用高斯混合模型确定地中海贫血的心肌 T2* 截止值
DOI：
10.1186/1532-429x-14-s1-o77
复制
发表时间：
2012-02-01
影响因子：
6.4
通讯作者：
Firmin DN
中科院分区：
文献类型：
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作者：
He T;Liu RR;Feng Y;Carpenter JP;Lai Y;Pennell DJ;Firmin DN
背景心血管磁共振（CMR）可以提供一种无创的测量组织铁含量的方法。铁导致质子弛豫时间缩短，CMR T2* 和T2均已被验证为评估心肌铁过载的非侵入性方法。（1、2、3、4）。我们已经报道，T2* 值低于20 ms表示心脏中的铁过载（5）。这个临界值虽然在临床实践中被证明非常有用，但在我们的初步报告中是基于15名正常志愿者的（5）。目前几乎没有数据来证实这一重要的临界值，该临界值已被广泛接受用于重型地中海贫血（TM）患者心肌铁的早期诊断。
BackgroundCardiovascular magnetic resonance (CMR) can provide a non-invasive means of measuring the amount of tissue iron. The iron results in shortening of proton relaxation times and both CMR T2* and T2 have been validated as non-invasive means for assessment of myocardial iron overload.(1, 2, 3, 4). We have reported that a T2* value below 20ms represents iron overload in the heart (5). This cut-off value, though proven very useful in clinical practice, was based on 15 normal volunteers in our initial report (5). There is currently little data to confirm this important cut-off value which has been widely accepted for early diagnosis of myocardial iron in patients with thalassemia major (TM).