Uniting functional network topology and oscillations in the fronto-parietal single unit network of behaving primates
Uniting functional network topology and oscillations in the fronto-parietal single unit network of behaving primates
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DOI：
10.7554/elife.15719
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发表时间：
2016-08-15
期刊：
影响因子：
7.7
通讯作者：
Scherberger, Hansjoerg
中科院分区：
文献类型：
--
作者：
Dann, Benjamin;Michaels, Jonathan A.;Scherberger, Hansjoerg
皮层网络中神经元的功能性通信是高级认知过程的基础。然而，人们对单神经元网络的组织结构及其与同步过程的关系知之甚少。在这里，我们表明，功能的单神经元网络的三个额顶叶地区在活跃的行为猕猴是非常复杂的。该网络紧密相连（小世界），由跨越这些领域的功能模块组成。令人惊讶的是，不同神经元对网络的重要性是高度异质的，少数神经元对网络功能（集线器）有很大的贡献，而这些神经元反过来又是紧密相连的（富俱乐部）。对网络同步的检查显示，所识别的富俱乐部由在β或低频范围内同步的神经元组成，而其他神经元大多是非振荡同步的。因此，振荡同步可能是高度组织化的功能性尖峰网络的中心通信机制。
The functional communication of neurons in cortical networks underlies higher cognitive processes. Yet, little is known about the organization of the single neuron network or its relationship to the synchronization processes that are essential for its formation. Here, we show that the functional single neuron network of three fronto-parietal areas during active behavior of macaque monkeys is highly complex. The network was closely connected (small-world) and consisted of functional modules spanning these areas. Surprisingly, the importance of different neurons to the network was highly heterogeneous with a small number of neurons contributing strongly to the network function (hubs), which were in turn strongly inter-connected (rich-club). Examination of the network synchronization revealed that the identified rich-club consisted of neurons that were synchronized in the beta or low frequency range, whereas other neurons were mostly non-oscillatory synchronized. Therefore, oscillatory synchrony may be a central communication mechanism for highly organized functional spiking networks.