ACUTE EXPOSURE TO MANEB ALTERS SOME BEHAVIORAL FUNCTIONS IN THE MOUSE
ACUTE EXPOSURE TO MANEB ALTERS SOME BEHAVIORAL FUNCTIONS IN THE MOUSE
复制标题
DOI：
10.1016/0892-0362(89)90018-4
复制
发表时间：
1989-09-01
影响因子：
2.9
通讯作者：
TAKAHASHI, RN
中科院分区：
文献类型：
--
作者：
MORATO, GS;LEMOS, T;TAKAHASHI, RN
代森锰是一种有机锰杀菌剂，主要在农业地区用于控制大田作物病理。尽管其毒性明显较低，但有报告表明代森锰对周围和中枢神经系统具有有害影响。在这项工作中，在一些实验动物模型上研究了急性施用代森锰的影响。雄性成年小鼠接受数剂量的代森尼布（IP）治疗，并接受总体行为观察（200-1000毫克/千克）和运动活动、巴比妥诱导的睡眠时间、隔离诱导的攻击性、紧张症、攀爬行为和旋转杆性能（30、60和100毫克/千克）的测量。结果表明，代森锰对运动活动和攻击性具有抑制作用，并增加巴比妥引起的睡眠时间和氟哌啶醇引起的紧张症。然而，代森锰并不影响阿扑吗啡引起的动物攀爬行为。这些数据表明代森锰具有类似中枢神经系统抑制剂的作用，并且至少部分地表明多巴胺能系统参与了这种作用的介导。
Maneb, an organomanganese fungicide, is largely used in agricultural regions for control of field crop pathologies. Despite its apparent low toxicity, there are reports showing that maneb has harmful effects on peripheral and central nervous systems. In this work the effects of acute administration of maneb were studied on some experimental animal models. Male adult mice were treated with several doses of maneb, IP, and submitted to gross behavioral observation (200-1000 mg/kg) and measurement of locomotor activity, barbiturate-induced sleeping time, isolation-induced aggressiveness, catatonia, climbing behavior and of rota-rod performance (30, 60 and 100 mg/kg). The results showed that maneb has an inhibitory effect on locomotor activity and aggressiveness and increases barbiturate-induced sleeping time and haloperidol-induced catatonia. However, maneb did not affect the apomorphine-induced climbing behavior of animals. These data indicate that maneb has a CNS depressant-like effect, and suggest, at least partially, the involvement of dopaminergic systems in the mediation of this effect.