A software tool for interactive exploration of intrinsic functional connectivity opens new perspectives for brain surgery
A software tool for interactive exploration of intrinsic functional connectivity opens new perspectives for brain surgery
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DOI：
10.1007/s00701-011-0985-6
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发表时间：
2011-08-01
影响因子：
2.4
通讯作者：
Abbushi, Alexander
中科院分区：
文献类型：
--
作者：
Boettger, Joachim;Margulies, Daniel S.;Abbushi, Alexander
静息态功能磁共振成像数据的功能连接性分析（fcrs - fMRI）已被证明是一种用于定位功能网络（无需使用特定任务）的稳健的非侵入性方法，并且在术前规划方面具有应用前景。然而，为了将该方法应用于日常临床实践，fcrs - fMRI需要进一步验证，并使神经外科医生能够方便地使用。本文通过介绍一种为神经外科医生设计的用于分析和可视化fcrs - fMRI数据的软件工具来解决后一个问题。开发了一种原型交互式可视化工具，使神经外科医生能够探索功能连接性数据并评估其可用性。该工具的实现基于LIPSIA（一种用于评估功能性神经影像数据的成熟软件包），并将感兴趣区域的选择与功能连接区域的计算和可视化相结合。该工具用于探索一名健康参与者和八名脑损伤患者的数据。四位之前不熟悉该方法的神经外科医生对该软件的可用性进行了评估，他们被要求识别显著的大规模皮质网络。使用这种新型工具，重现了先前发表的研究结果，例如感觉运动皮层的肿瘤移位以及功能网络的其他紊乱。神经外科医生能够始终如一地获得与专家相似的结果，但语言网络除外。即时反馈有助于快速、直观地确定功能网络，即使是没有经验的用户每个网络也只需不到3分钟。尽管fcrs - fMRI是一种新兴的方法，相对于既定标准仍在接受评估，但这种交互式软件仍然是神经外科实践中对个体功能连接网络进行非侵入性探索的一种有前途的工具，无论是对于众所周知的网络还是那些不太常见的网络。
Functional connectivity analysis of resting-state functional magnetic resonance imaging data (fcrs-fMRI) has been shown to be a robust non-invasive method for localization of functional networks (without using specific tasks) and to be promising for presurgical planning. However, in order to transfer the approach to everyday clinical practice, fcrs-fMRI needs to be further validated and made easily accessible to neurosurgeons. This paper addresses the latter by presenting a software tool designed for neurosurgeons for analyzing and visualizing fcrs-fMRI data.A prototypical interactive visualization tool was developed to enable neurosurgeons to explore functional connectivity data and evaluate its usability. The implementation builds upon LIPSIA, an established software package for the assessment of functional neuroimaging data, and integrates the selection of a region-of-interest with the computation and visualization of functionally connected areas. The tool was used to explore data from a healthy participant and eight brain lesion patients. The usability of the software was evaluated with four neurosurgeons previously unacquainted with the methodology, who were asked to identify prominent, large-scale cortical networks.With this novel tool, previously published findings, such as tumor displacement of the sensorimotor cortex and other disturbances of functional networks, were reproduced. The neurosurgeons were able to consistently obtain results similar to the results of an expert, with the exception of the language network. Immediate feedback helped to pinpoint functional networks quickly and intuitively, with even inexperienced users requiring less than 3 min per network.Although fcrs-fMRI is a nascent method still undergoing evaluation with respect to established standards, the interactive software is nonetheless a promising tool for non-invasive exploration of individual functional connectivity networks in neurosurgical practice, both for well-known networks and for those less typically addressed.