Decreased hippocampal NMDA, but not kainate or AMPA receptors in bipolar disorder
Decreased hippocampal NMDA, but not kainate or AMPA receptors in bipolar disorder
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DOI：
10.1034/j.1399-5618.2003.00024.x
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发表时间：
2003-08-01
影响因子：
5.4
通讯作者：
Dean, B
中科院分区：
文献类型：
--
作者：
Scarr, E;Pavey, G;Dean, B
目的：探讨双相情感障碍患者海马区亲离子谷氨酸受体密度的变化。方法：采用放射配基原位结合半定量放射自显影技术，测定了双相情感障碍患者海马区[H-3]MK-801、[H-3]CGP39653、[H-3]AMPA和[H-3]海人藻氨酸结合密度。结果：在双相情感障碍患者中，[H-3]MK-801结合密度显著降低(平均+/-扫描电子显微镜；108.8+/-12.2fmol/mgETE与166.2+/-18.0fmol/mgETE，p
Objectives: The purpose of this study was to determine whether are changes in the density of ionotropic glutamate receptors in the hippocampus of subjects with bipolar disorder.Methods: Using in situ radioligand binding with semiquantitative auto radiography I we measured the density of [H-3]MK-801, [H-3]CGP39653, [H-3]AMPA and [H-3]kainate binding in hippocampi, obtained postmortem, from eight subjects with type 1 bipolar disorder and 8 age- and sex-matched controls.Results: In subjects with bipolar disorder there were significant decreases in the density of [H-3]MK-801 binding in the Cornu Ammonis (CA) 3 (mean+/-SEM; 108.8+/-12.2 versus 166.2+/-18.0 fmol/mg ETE, p