Methodology to obtain a mixed sural nerve recording in mice.
Methodology to obtain a mixed sural nerve recording in mice.
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DOI：
10.1097/phm.0b013e31819c575b
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发表时间：
2009-07
影响因子：
3
通讯作者：
Carrion-Jones MJ
中科院分区：
文献类型：
--
作者：
Dunham MW;James SE;Lever TE;Lu Q;Carrion-Jones MJ
使用小鼠模型进行电诊断研究的兴趣越来越大。研究具有各种病理的转基因小鼠，增加了我们对疾病自然史的了解。然而，必须将疾病模型与适当的对照进行比较。因此，为了将这些动物用于电诊断研究，必须设定参考值。如果没有参考值，数据的有效性就很成问题。我们提出了一种获得混合神经动作电位的方法，并从小鼠腓肠神经收集参考值。结果是右侧的平均峰值潜伏期为1.74 ms，左侧为1.89 ms。平均振幅左侧为17.0 μV，右侧为21.6 μV。在未来的研究中，这些参考值可以成为分析小鼠受试者的有用工具。
There is increasing interest in using mouse models for electrodiagnostic research. Studying transgenic mice with various pathologies, add to our knowledge of the natural history of a disease. It is imperative, however, to compare disease models to the appropriate control. Therefore, in order for these animals to be used in electrodiagnostic research, reference values must be set. If reference values are not available, the validity of data is highly questionable. We propose a method of obtaining mixed nerve action potentials and collect reference values from the sural nerve of mice. The results were a mean peak latency of 1.74 ms on the right and 1.89 ms on the left. The mean amplitude was 17.0 μV on the left and 21.6 μV on the right. In future studies, these reference values can be useful tools in analysis of murine subjects.