Maternal Pesticide Exposure and Neural Tube Defects in Mexican Americans
Maternal Pesticide Exposure and Neural Tube Defects in Mexican Americans
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DOI：
10.1016/j.annepidem.2009.09.011
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发表时间：
2010-01-01
影响因子：
5.6
通讯作者：
Henry, Judy P.
中科院分区：
文献类型：
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作者：
Brender, Jean D.;Felkner, Marilyn;Henry, Judy P.
目得：在184名墨西哥裔美国病例妇女和225名对照妇女中评估了母体农药暴露与后代神经管缺陷（NTDs）之间的关系。方法：在围怀孕期进行面对面访谈，收集有关环境和职业农药暴露的信息。在调整了母亲的教育、吸烟和叶酸摄入量后，报告在家中或院子里使用杀虫剂的妇女，（95%置信区间[Cl]，1.2-3.1）有NTD影响的怀孕比妇女没有这些报告的暴露。与对照组相比，病例组女性也更有可能报告居住在耕地0.25英里以内（比值比为3.6; 95% CI，1.7-7.6）。随着农药暴露机会的增加，NTD的风险也增加了。一个、两个和三个或更多暴露源的校正OR和95% CI为1.2（0.69-1.9）、2.3（1.3-4.1）和2.8（1.2-6.3），无脑畸形的风险比脊柱裂的风险更大。在本研究人群中，自我报告的农药暴露与NTD风险相关，特别是在家中和距耕地0.25英里内的围产期居住地使用农药。Ann Epidemiol 2010;20：16-22. (C)2010年爱思唯尔公司All rights reserved.
PURPOSE: The relation between maternal pesticide exposures and neural tube defects (NTDs) in offspring was evaluated in 184 Mexican American case-women and 225 comparison women.METHODS: In-person interviews solicited information about environmental and occupational exposures to pesticides during the periconceptional period.RESULTS: With adjustment for maternal education, smoking, and folate intake, women who reported using pesticides in their homes or yards were two times more likely (95% confidence interval [Cl], 1.2-3.1) to have NTD-affected pregnancies than women without these reported exposures. Case-women were also more likely to report living within 0.25 mile of cultivated fields than control-women (odds ratio FOR] 3.6; 95% CI, 1.7-7.6). As sources of pesticide exposure opportunities increased, risk of NTDs also increased. The adjusted ORs and 95% CIs for one, two, and three or more exposure sources were 1.2 (0.69-1.9), 2.3 (1.3-4.1) and 2.8 (1.2-6.3) respectively, and this positive trend was stronger for risk of anencephaly than for spina bifida.CONCLUSIONS: Self-reported pesticide exposures were associated with NTD risk in this study population, especially use of pesticides within the home and a periconceptional residence within 0.25 mile of cultivated fields. Ann Epidemiol 2010;20:16-22. (C) 2010 Elsevier Inc. All rights reserved.