Whither Ribosome Structure and Dynamics Research? (A Perspective)
Whither Ribosome Structure and Dynamics Research? (A Perspective)
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DOI：
10.1016/j.jmb.2016.04.034
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发表时间：
2016-09-11
影响因子：
5.6
通讯作者：
Frank, Joachim
中科院分区：
文献类型：
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作者：
Frank, Joachim
作为高分辨率低温电子显微镜（cryo-EM）的结构的核糖体增殖，在决议，使原子相互作用可视化，本文试图给出一个角度的方式研究核糖体结构和动力学可能会领导，特别是新的机会，我们已经获得了通过最近的进展，在cryo-EM。指出单分子FRET和cryo-EM在体外翻译系统的核糖体动力学和平衡状态之间的转换的表征中形成天然互补。(C)2016爱思唯尔有限公司版权所有
As high-resolution cryogenic electron microscopy (cryo-EM) structures of ribosomes proliferate, at resolutions that allow atomic interactions to be visualized, this article attempts to give a perspective on the way research on ribosome structure and dynamics may be headed, and particularly the new opportunities we have gained through recent advances in cryo-EM. It is pointed out that single-molecule FRET and cryo-EM form natural complements in the characterization of ribosome dynamics and transitions among equilibrating states of in vitro translational systems. (C) 2016 Elsevier Ltd. All rights reserved.